摘要
目的探讨Stanford A型主动脉夹层患者血浆骨桥蛋白(OPN)表达水平及其临床意义。方法入选51例Stanford A型主动脉夹层患者(其中合并高血压29例,未合并高血压22例),同时选取14例单纯高血压患者及11名健康者作为对照。ELISA法检测血浆OPN水平。结果与健康对照者相比,主动脉夹层患者的血浆OPN水平显著升高[(234.9±20.5)pg/ml比(26.0±25.9)pg/ml,P<0.001]。与单纯高血压组[(24.6±21.9)pg/ml]及健康对照组[(26.0±25.9)pg/ml]相比,合并[(274.4±164.6)pg/ml]及未合并高血压的主动脉夹层患者[(182.8±99.5)pg/ml]的血浆OPN水平均显著升高(均为P<0.05)。Spearman相关性分析发现,主动脉夹层患者的血浆OPN水平与炎症指标C反应蛋白之间无显著相关性(r^2=0.06,P=0.09)。结论 OPN可能参与Stanford A型主动脉夹层的发生发展,但与血清C反应蛋白水平无相关性,其深入机制有待进一步研究。
Objective To explore the plasma expression and clinical significance of osteopontin （OPN） in patients with Stanford type A aortic dissection. Methods Fifty-one patients with Stanford type A aortic dissection were enrolled, in which 29 combined with hypertension, while the 22 without hypertension. Fourteen hypertensive patients and 11 healthy subjects were enrolled as controls. Plasma were sampled and examined for the level of OPN by enzyme linked immunosorbent assay （ELISA）. Results The levels of plasma OPN were significantly increased in patients with Stanford type A aortic dissection compared to healthy subjects [ （234. 9 ± 20. 5 ） pg/ml vs. （ 26.0 ± 25.9 ） pg/ml, P 〈 0. 001 ]. Type A aortic dissection patients with [ （ 274.4 ±164. 6 ） pg/ml ] or without hypertension [ （ 182. 8 ± 99. 5 ） pg/ml ] both showed significantly increased plasma OPN levels compared to hypertension patients [ （ 24. 6 ± 21.9 ） pg/ml ] or healthy controls [ （26.0 ± 25.9） pg/ml, all P 〈 0.05 ]. Spearman correlation analysis showed that there was no significant correlation between serum CRP levels and plasma OPN levels （ r2 = 0.06, P = 0. 09 ） . Conclusions Plasma OPN may be involved in the pathogenesis of Stanford type A aortic dissection, but their concentrations were not correlated with serum CRP levels. The detailed mechanism needs further investigations.
出处
《中国心血管杂志》
2015年第6期443-446,共4页
Chinese Journal of Cardiovascular Medicine
基金
南京大学中央高校基本科研业务费专项资金资助项目(20620140660)
南京市医学科技发展资金资助项目(YKK13071)~~
