摘要
作者对30例无糖尿病史的肝硬化患者进行了口服葡萄糖胰岛素释放试验。发现40％的患者糖耐量曲线异常,其中呈糖尿病型曲线者23.3％,损害型16.7％。60％的患者胰岛素释放试验曲线异常,其中分泌增高者为3.3％,高峰延迟者为40.0％,二者并存者为16.7％。
In order to investigate the disorders ofcarbohydrate metabolism and insulin secre-tion as well as their correlation in patientswith liver cirrhosis, we performed an oralglucose tolerance test on 30 patients withliver cirrhosis proven by history, clinicalfindings, liver function test, radioisotopeliver scanning, ultrasonic examination,gastroscopy, barium esophagogram and liverbiopsy, compared with 20 healthy controls.Blood glucose and immunoreactive insulinwere determined in both groups at 60 minintervals for 180 min. Results showed marked glucose intole-rance with peak value 60 rain after glucoseload in cirrhotic patients with normal fast-ing blood glucose. Plasma IRI levels weresignificantly higher in cirrhotic patientsthan in normal subjects after glucose load(P<0.05), especially 180 min after (P<0.01). Twelve of 30 cases (40%) showed anabnormal OGTT curve. Of the 12 casesseven (23.3%) showed a diabetic OGTTcurve, five (16.7%) an impaired OGTTcurve. While eighteen of 30 cases (60%)showed an abnormal OGIRT curve. Amongthe 18 eases one (3.3%) presented hyper-secretic OGIRT curve, twelve (40.0%) withdelayed and prolonged peak, and five (16.7%)with hypersecretic OGIRT curve anddelayed, prolonged peak.
出处
《华西医科大学学报》
CAS
CSCD
1989年第1期66-69,共4页
Journal of West China University of Medical Sciences
关键词
糖代谢
胰岛素
肝硬变
门脉分流
Carbohydrate metabolism
Insulin
Oral glucose
tolerance test Oral glucose insulin releasing test
Cirrhosis
Porto-systemic shunting
