摘要
目的观察硫辛酸联合前列地尔治疗2型糖尿病下肢血管神经病变的临床效果。方法选取2011年6月至2014年9月新乡市中心医院收治的2型糖尿病下肢血管神经病变患者96例,按治疗方法分为常规治疗组、前列地尔组、硫辛酸组和联合治疗组,每组24例。常规治疗组患者给予降血糖、降血压、降血脂等常规治疗,在常规治疗的基础上,前列地尔组患者给予前列地尔治疗,硫辛酸组患者给予硫辛酸治疗,联合治疗组患者给予前列地尔和硫辛酸治疗,疗程为4周;观察患者治疗前、治疗1、2、3、4周及治疗结束后1个月的踝臂指数(ABI)、足背动脉血流速度及内径变化、足背皮肤温度及静息痛指数。结果治疗前4组患者ABI比较差异均无统计学意义(P>0.05)。治疗1、2、3、4周及治疗结束后1个月时,前列地尔组、硫辛酸组和联合治疗组患者ABI均显著高于常规治疗组(P<0.05),联合治疗组患者ABI显著高于前列地尔组和硫辛酸组(P<0.05)。治疗前4组患者足背动脉血流速度及内径比较差异均无统计学意义(P>0.05)。治疗1、2、3、4周及治疗结束后1个月时,前列地尔组、硫辛酸组和联合治疗组患者足背动脉血流速度均显著高于常规治疗组(P<0.05),联合治疗组患者足背动脉血流速度显著高于前列地尔组和硫辛酸组(P<0.05)。治疗1、2、3、4周及治疗结束后1个月时,前列地尔组、硫辛酸组和联合治疗组患者足背动脉内径均显著大于常规治疗组(P<0.05),联合治疗组患者足背动脉内径均显著大于前列地尔组和硫辛酸组(P<0.05)。前列地尔组和硫辛酸组患者足背皮肤温度及下肢静息疼改善显著优于常规治疗组(P<0.05),联合治疗组患者足背皮肤温度及下肢静息疼改善显著优于前列地尔组和硫辛酸组(P<0.05)。结论前列地尔联合硫辛酸治疗2型糖尿病下肢血管神经病变可显著改善ABI、足背动脉血流速度和内径、足背皮肤温
Objective To observe the effect of lipoic acid combined with alprostadil on angioneuropathy of the lower limb in patients with type 2 diabetes mellitus. Methods A total of 96 patients with type 2 diabetes mellitus and angioneuropathy of the lower limb were selected in the Central Hospital of Xinxiang City from June 2011 to September 2014,then the patients were divided into conventional therapy group,alprostadil group,thioctic acid group and combined treatment group,24 cases in each group. The patients in conventional therapy group were treated with insulin,decreasing blood pressure,decreasing blood lipids and other conventional treatment. Based on these,the patients in alprostadil group were treated with alprostadil,the patients in thioctic acid group were treated with thioctic acid,and the patients in combined treatment group were treated with alprostadil and thioctic acid. The course of treatment was four weeks. The ankle brachial index（ ABI）,blood flow velocity of dorsal pedis artery,internal diameter of dorsal pedis artery,skin temperature of dorsi pedis and rest pain index were observed at the time points of before treatment,treatment for 1,2,3,4 weeks and 1 month after treatment. Results There was no significant difference in ABI between the two groups before treatment（ P〈0. 05）. At the time points of 1,2,3,4 weeks of treatment and one month after treatment,the ABI in alprostadil group,thioctic acid group and combined treatment group was significantly higher than that in conventional therapy group（ P〈0. 05）; the ABI in combined treatment group was significantly higher than that in alprostadil group and thioctic acid group（ P〈0. 05）. There was no significant difference in the blood flow velocity and internal diameter of dorsal pedis artery between the two groups before treatment（ P〉0. 05）. At the time points of 1,2,3,4weeks of treatment and 1 month after treatment,the blood flow velocity of dorsal pedis artery in alprostadil group,thioctic acid group and combined treatment group w
出处
《新乡医学院学报》
CAS
2015年第12期1128-1131,共4页
Journal of Xinxiang Medical University
关键词
糖尿病
血管病变
神经病变
前列地尔
硫辛酸
diabetes mellitus
vasculopathy
neuropathy
alprostadil
thioctic acid
