摘要
目的探讨支气管哮喘的遗传方式及筛选有关其危险因素,评估各主要危险因素对发病的相对重要性,为哮喘的三级预防提供理论依据。方法选取潍坊医学院附属医院儿科门诊及住院的100例支气管哮喘患儿。通过Falconer回归法和Li-Mantel-Cart法估计支气管哮喘的遗传度和分离比。将调查资料转化为等级分组资料以便于信息录入,将以上信息输入SPSS 21数据窗口进行统计学估计。先对所有因素进行卡方检验,筛选出对哮喘发病有影响的因素,然后对筛选出的因素进行条件Logistic回归分析,筛选出主要危险因素。结果支气管哮喘一级亲属遗传度为84.05%,二级亲属遗传度为68.84%,一、二级亲属平均加权遗传度为78.87%±6.99%;Li-Mantel-Cart法分别估计哮喘的遗传度和分离比分离比P=0.1041。分离比<0.25。通过卡方检验对各因素进行筛选,家族哮喘、过敏、湿疹、反复呼吸道感染等因素与哮喘的发病具有统计学意义。结论支气管哮喘为多基因遗传病,一级亲属遗传度为84.05%,二级亲属遗传度为68.84%,一、二级亲属平均加权遗传度为78.87%±6.99%。分离比P=0.163。避免过敏、湿疹、支原体感染可预防支气管哮喘的发生。
Objective To investigate the genetic pattern and screen its relative risk factors of bronchial asthma,and to evaluate the relative importance of the major risk factors for the disease.Methods One hundred cases of bronchial asthma were selected from the out-patient and inpatient departments of pediatrics from the affiliated hospital of weifang medical university.Falconer regression method and Li-Mantel-Cart method were used to estimate the degree of inheritance and separation of bronchial asthma.The survey data were transformed into hierarchical grouping data in order to facilitate the information input,and all information was entered into the SPSS 21 data window for statisti-cal estimation.All the factors were tested by chi-square test,the factors affecting the incidence of asthma were selected,and the main risk fac-tors were screened out by Logistic regression analysis.Results The degree of inheritance of the first degree relatives of bronchial asthma was 84.05%,and the degree of inheritance of the two relatives was 68.84%,and the average weight of one or two degree relatives was 78.87%±6.99%.The separation ratio is less than 0.25.During our tests,we found that the incidence of asthma and these factors has statistical sig-nificance,including family asthma,allergies,eczema,and recurrent respiratory tract infections.Conclusion Bronchial asthma is a multi gene genetic disease,the separation ratio is 0.163.To avoid allergies,eczema,mycoplasma infection can prevent the occurrence of bronchial asth-ma.
出处
《潍坊医学院学报》
2015年第6期442-444,共3页
Acta Academiae Medicinae Weifang
