摘要
目的回顾性分析血清绒毛膜促性腺激素β亚单位(β-HCG)联合孕酮检测在异位妊娠(EP)早期诊断中的价值。方法选取50例异位妊娠患者作为治疗组,并设同期正常早孕孕妇50例作为对照组,2组受试者分别于孕龄30、40、50 d清晨空腹抽取静脉血5 m L,采用放射免疫法检测β-HCG和孕酮水平,观察2组血清β-HCG和孕酮水平变化,血清β-HCG联合孕酮测定与单独β-HCG测定对EP的特异度、敏感度及诊断符合率。结果 2组孕龄第30天β-HCG水平比较无统计学意义(P>0.05),治疗组孕酮低于对照组,有统计学意义(P<0.05);孕龄第40天、50天β-HCG和孕酮水平治疗组显著低于对照组(P<0.05);血清β-HCG联合孕酮测定对EP的特异度、敏感度及诊断符合率明显高于单独β-HCG测定,P<0.05。结论血清β-HCG联合孕酮检测对EP的诊断符合率明显较单项β-HCG检测占优势,尤其对症状和体征不典型的早孕患者,可弥补单项β-HCG检测的不足,可为临床早期治疗赢得时间。
Objective To explore the value of serum β-HCG combined with progesterone assay in early diagnosis of ectopic pregnancy（ EP）. Methods A total of 50 EP patients as the observation group,while 50 early pregnant women at the same stage were served as the control group. A volume of 5m L morning fasting venous blood in the two groups at gestational age of 30 d,40d and 50 d was extracted. RIA was used to detect the levels of β-HCG and progesterone. The changes of serum β-HCG and progesterone levels were observed. The specificity,sensitivity,and diagnostic accordance rate by the combination determination or a single β-HCG determination were detected. Results The comparison of β-HCG level at gestational age of 30 d between the two groups was not statistically significant（ P〈0. 05）,while the progesterone level in the observation group was significantly lower than that in the control group（ P〈0. 05）. The β-HCG and progesterone levels at gestational age of 40 d and 50 d in the observation group were significantly lower than those in the control group（ P〈0. 05）. The specificity,sensitivity,and diagnostic accordance rate by the combination determination were significantly higher that those by a single β-HCG determination（ P〈0. 05）. Conclusion The diagnostic accordance rate of EP by serum β-HCG in combined with progesterone assay is significantly superior to that by a single β-HCG determination,especially in the early pregnant women with atypical symptoms and signs,the combination determination can compensate for the deficiency by a single β-HCG determination,and is of great significance in the diagnosis of an early EP,thus,gaining time for an early treatment in the clinic.
出处
《长春中医药大学学报》
2015年第6期1277-1279,共3页
Journal of Changchun University of Chinese Medicine
基金
河北省张家口市计划外科研课题(2015)
