摘要
目的探讨醋酸钙对维持性血液透析患者高磷血症的治疗效果。方法将84例血液透析高磷血症患者随机分为治疗组(n=43)和对照组(n=41),治疗组给予餐中口服醋酸钙,9片/d;对照组给予餐中口服碳酸钙,9片/d,疗程共12 w,分别于治疗前及治疗后每2 w,检测两组透析前的血钙、磷、i PTH水平。结果两组血磷水平于治疗开始后均逐渐下降,自治疗4 w起,治疗组血磷水平均低于对照组(P<0.05)。治疗前,两组血钙水平正常,治疗后两组血钙水平均随口服药物时间增长而升高,至6 w后血钙水平趋于稳定,自治疗4 w起,对照组血钙水平均明显高于治疗组(P<0.05)。两组血i PTH水平在12 w观察期内无显著差异(P>0.05)。结论口服醋酸钙可有效降低维持性血液透析高磷血症患者血磷水平,减少高钙血症风险,值得临床推广应用。
Objective To investigate the curative effect of calcium acetate on hyperphosphatemia of patients receiving maintenance hemodialysis, Methods 84 cases of hyperphosphatemia that received maintenance hemodialysis were randomly divided into treatment group (n=43) and control group (n=41). The treatment group was given calcium acetate 9 pieces/d during the meal, and the control group was given calcium carbonate 9 pieces/d. The course of treatment was 12 weeks. The blood calcium, phosphorus, and the entire section iPTH levels before the dialysis were detected every two weeks before and after the treatment, Results The blood phosphorus levels in both groups decreased after the beginning of the treatment. Since the fourth week of the treatment, the blood phosphorus levels in the treatment group were lower than those in the control group(P 〈 0.05). Before the treatment, the blood calcium levels in both groups were normal; after the treatment, those levels increased with the time of oral administration. Since the 6th week, the blood calcium levels were stable. After the 4th week of treatment, the blood calcium levels in the control group were significantly higher than those in the treatment group (P 〈 0.05). There was no significant difference in the iPTH levels between the two groups in the observation period of 12 weeks (P 〉 0.05). Conclusion Oral administration with calcium acetate can effectively reduce the blood phosphorus levels of patients with hypercalcemia who received maintenance hemodialysis and the risk of hypercalcemia. It is worthy of clinical application.
出处
《西南国防医药》
CAS
2015年第12期1289-1291,共3页
Medical Journal of National Defending Forces in Southwest China
关键词
醋酸钙
血液透析
高磷血症
疗效
calcium acetate
hematodialysis
hyperphosphatemia
curative effect