摘要
目的评价胃泌素释放肽前体（Pro GRP）对小细胞肺癌（SCLC）的诊断价值。方法选取2013年2月至2014年4月在蚌埠医学院第一附属医院住院治疗的70例SCLC患者（SCLC组）、40例非小细胞肺癌（NSCLC）患者（NSCLC组）及30例肺良性疾病（BDP）患者（BDP组）作为研究对象。采用化学发光免疫分析法和放射免疫分析法检测患者血清中Pro GRP和NSE的水平,探讨ProGRP诊断SCLC的价值。结果 SCLC组患者血清中Pro GRP[1088.05（437.51,2294.03）ng/L]和NSE[15.11（9.52,25.10）μg/L]的水平均显著高于NSCLC组[43.26（32.13,49.17）ng/L、[7.24（5.32,9.99）μg/L]和BPD组[38.46（30.81,43.72）ng/L、7.27（4.81,9.71）μg/L]（P〈0.05）。以BPD为对照组,受试者工作特征（ROC）曲线确定的血清Pro GRP诊断SCLC的截断点为52.29 ng/L,ROC曲线下面积为0.982,95%CI 0.959~1.005;以NSCLC组为对照,血清Pro GRP和NSE的ROC曲线下面积分别为0.973和0.764,两者比较差异有统计学意义（Z=4.26,P〈0.05）,获得Pro GRP诊断SCLC的截断点为86.96 ng/L。Pro GRP诊断SCLC的灵敏度、特异性、阳性预测值、阴性预测值及约登指数分别为88.6%、96.7%、98.4%、78.4%及0.852,均高于NSE的60.0%、90.0%、93.3%、49.1%、0.5。结论血清Pro GRP的水平对SCLC有较高的辅助诊断价值。
Objective To evaluate the diagnositic value of pro-gastrin-releasing peptide （ProGRP） in small cell lung carcinoma（SCLC）. Methods From Feb. 2013 to Apr. 2014,70 SCLC patients （SCLC group） ,40 NSCLC patients（ NSCLC group） and 30 benign pulmonary diseases （BPD group） in the First Affiliated Hospital of Bengbu Medical College were selected. The levels of serum ProGRP and NSE in the three groups were determined by chemiluminescent immunoassay and radioimmunoassay,respectively, and the diagnostic value of ProGRP in SCLC was investigaged. Results The serum ProGRP [ 1088.05 （437.51, 2294. 03） ng/L] and NSE [ 15.11 （9.52,25.10） μg/L] levels of SCLC group were significantly higher than those in NSCLC group [ 43.26 （ 32. 13,49. 17 ） ng/L, 7.24 （ 5.32,9.99 ） μg/L ] and BPD group [ 38.46 （30. 81,43.72 ） ng/L,7.27 （4. 81,9.71 ） μg/L ] （ P 〈 0. 05 ）. BPD served as control group, the cut-off point of ProGRP was 52.29 ng/L, the area under the curve about receiver operator characteristic was O. 982,95% CI 0. 959-1. 005. NSCLC group served as the control, the area under the curve about receiver operator characteristic of ProGRP and NSE were 0. 973 and 0. 764, respectively. The area under curve of ProGRP was larger than NSE （ Z = 4. 670, P 〈 0.05 ）, the cut-off point of ProGRP diagnosing SCLC was 86.96 ng/L. The sensitivity, specificity, positive predictive value, negative predictive value and Youden＇s index for SCLC were 88.6% ,96.7% ,98.4% ,78.4% and 0. 852,respectively,which were higher than the 60.0% ,90.0% ,93.3% ,49. 1% ,0. 5 for NSE. Conclusion ProGRP is quite helpful as auxiliary diagnosis in SCLC.
出处
《医学综述》
2015年第24期4552-4554,共3页
Medical Recapitulate
