摘要
目的探究联合检测血清降钙素原（PCT）、白细胞计数（WBC）在脓毒症患儿感染情况及病情程度诊断中的应用价值。方法选取2013年1月—2014年1月收治的符合脓毒症诊断标准的患儿80例,按照病情严重程度分为脓毒症组和严重脓毒症组,每组40例。另选取同期住院的非脓毒症患儿36例作为对照组。患者入院后24 h内均检测血清中PCT、WBC、C反应蛋白（CRP）水平并进行比较。比较PCT单独检测及PCT联合WBC检测诊断脓毒症的价值。结果严重脓毒症组患儿血清中PCT、WBC、CRP含量最高,分别为（2.88±1.31）μg/L、（17.0±6.6）×10-9/L、（124.8±15.9）mg/L,均明显高于其他2组（F=4.881、5.052、5.456,P〈0.05）,且息儿血清PCT阳性率为85.0%,高于脓毒症组患儿的57.5%和对照组的2.7%,3组患儿的PCT阳性率比较差异有统计学意义（F=7.34,P〈0.05）。PCT、WBC联合检测诊断脓毒症的敏感度、特异度、准确率、阳性预测值、阴性预测值、约登指数分别为87.5%、95.0%、91.3%、94.6%、88.4%、0.825,均明显高于PCT单独检测的57.5%、80.0%、68.8%、74.2%、65.3%、0.375（P〈0.05）。结论 PCT在脓毒症的诊断中具有较高的应用价值,其与WBC计数联合检测后,诊断准确率明显提高。
Objective To explore the application value of combined detection of serum procalcitonin（PCT）,white blood cell count（WBC） in the diagnosis of sepsis in children with sepsis.Methods From January 2013 to January 2014,according to the severity of the disease,80 children with sepsis were divided into sepsis group and severe sepsis group with 40 cases in each group.A control group of 36 patients with non sepsis patients were selected as the control group.The serum levels of PCT,WBC,CRP were detected in 24 h after admission.Results Severe sepsis group,serum PCT and WBC,CRP levels were the highest,（2.88±1.31）μg/L,（17.0±6.6）×10-9/L,（124.8±15.9）mg/L respectively,which were significantly higher than those in the other two groups（F=4.881,F=5.052,F=5.456,P〈0.05）,and the serum PCT positive rate was 85.0%,which were higher than the group of children with sepsis（57.5%） and the control group（2.7%）.The positive rate of PCT was statistically significant different between the 3 groups（F=7.34,P〈0.05）.PCT and WBC combined detection in the diagnosis of sepsis＇ s sensitivity,specificity,accuracy,positive predictive value,negative predictive value,Youden index were 87.5%,95.0%,91.3%,94.6%,88.4%,0.825,which were significantly higher than those of the separate detecting＇s 57.5%,80.0%,68.8%and 74.2%,65.3%,0.375（P〈0.05）.Conclusion The PCT has high application value in the diagnosis of sepsis,and the diagnostic accuracy is significantly improved with the combination of WBC count.
出处
《疑难病杂志》
CAS
2015年第12期1266-1268,1272,共4页
Chinese Journal of Difficult and Complicated Cases
关键词
降钙素原
脓毒症
白细胞
C-反应蛋白
Procalcitonin
Sepsis
White blood cell
C reactive protein
