摘要
目的 探讨依达拉奉联合奥扎格雷治疗大面积脑梗死的临床效果。方法 选取2011年1月~2014年12月收治的80例大面积脑梗死患者作为研究对象,按照随机数字表法分为观察组和对照组,各40例。两组均采用降颅压、调内环境、改善循环和脑保护治疗,在此基础上,对照组采用奥扎格雷治疗,观察组采用依达拉奉联合奥扎格雷治疗。比较两组治疗前后的血液黏度指标、MMSE及ADL评分,统计两组的临床效果。结果 观察组治疗后的MMSE评分显著高于治疗前及对照组治疗后,差异有统计学意义（P〈0.05）。观察组治疗后的ADL评分显著低于治疗前及对照组治疗后,差异有统计学意义（P〈0.05）。观察组治疗后的全血黏度及血浆黏度显著低于治疗前及对照组治疗后,差异有统计学意义（P〈0.05）。观察组的愈显率显著高于对照组,差异有统计学意义（P〈0.05）。结论依达拉奉联合奥扎格雷治疗大面积脑梗死效果显著,能够降低血液黏度,改善神经功能缺损,提高患者预后。
Objective To explore the clinical effect of edaravone combined with ozagrel in the treatment of massive cerebral infarction. Methods 80 patients with massive cerebral infarction from January 2011 to December 2014 in our hospital were selected and divided into the observation group and the control group according to a random number table method.Treatments like lowering down intracranial pressure,regulating internal environment,improving circulation and brain protecting were adopted in two groups.The control group was treated with ozagrel,the observation group was treated with edaravone combined with ozagrel.The index of blood viscosity,the score of mini-mental state examination （MMSE） and activities of daily life （ADL） before and after treatment was compared in two groups respectively.The clinical effect was statistically calculated. Results The MMSE score after treatment in the observation group was higher than that before treatment and in the control group after treatment,with significant difference （P〈0.05）.The ADL score after treatment in the observation group was lower than that before treatment and in the control group after treatment,with significant difference （P〈0.05）.The whole blood viscosity and plasma viscosity after treatment in the observation group was lower than that before treatment and in the control group after treatment,with significant difference （P〈0.05） .The cured and markedly effective rate in the observation group was higher than that in the control group,with significant difference （P〈0.05）. Conclusion The effect of edaravone combined with ozagrel in the treatment of massive cerebral infarction is significant,which can reduce blood viscosity,and improve neurological deficit as well as patient＇s prognosis.
出处
《中国当代医药》
2015年第34期64-66,共3页
China Modern Medicine
关键词
依达拉奉
奥扎格雷
大面积
脑梗死
Edaravone
Ozagrel
Large area
Cerebral infarction
