摘要
非酒精性脂肪肝(NAFLD)是一种慢性肝脏损害性疾病,其在过去的二十年内迅速地增长,其药物治疗效果有限且有一定的副作用。类黄酮是具有多种生理功能的一类天然物质,其对NAFLD的防治作用也日益引起人们的关注。大量细胞和动物实验的研究结果表明,类黄酮能降低肝脏内脂质累积,通过影响肝脏氧化应激、炎症及胰岛素抵抗等多方面改善NAFLD。本文从NAFLD的发病机制出发,概述近几年国内外关于类黄酮防治NAFLD的研究进展。
Non-alcoholic fatty liver disease（NAFLD） refers to a wide spectrum of liver disease that was not from excess alcohol consumption. The prevalence of NAFLD was rising dramatically in the past 20 years. Current NAFLD therapies were limited,thus,much attention had been focused on new strategies for NAFLD treatment.Dietary natural compounds such as flavonoids could prevent and improve NAFLD through a variety of mechanisms. A number of in vitro and in vivo studies have strongly suggest that dietary intake of flavonoids could interfere with the progression of NAFLD via inhibiting hepatic oxidative stress,inflammation,and insulin resistance. Based on NAFLD pathogenesis,the recent studies about the effects of flavonoids on NAFLD were reviewed in this work.
出处
《食品工业科技》
CAS
CSCD
北大核心
2015年第24期391-396,共6页
Science and Technology of Food Industry
基金
国家十二五科技支撑计划(2012BAH30F03)
