摘要
中医"脑心同治"理论对心脑血管疾病治疗的意义重大。尽管"脑心同治"在中医临床应用广泛,但其潜在的机制尚未得到全面的阐释。为了科学揭示"脑心同治"的机制,该研究基于数据科学的思想以心脑血管疾病中最具有代表性的2种疾病——脑中风和冠心病为例,对"脑心同治"机制进行深入挖掘。该研究从药物、靶标、通路、疾病多个角度出发,整合应用各类数据资源,采用文本挖掘、生物网络以及富集分析方法来识别心脑血管疾病间的潜在关联特征以及具有"同治"功能的药物特性,从而从多个水平揭示"脑心同治"的潜在机制。
The traditional Chinese medicine（ TCM） theory of ″treating heart and brain diseases with same methods（ Nao Xin Tong Zhi： NXTZ） ″ has great significance to the treatment of cardiovascular and cerebrovascular diseases. It has been proven effective by a great deal of clinical researches. However,the underlying mechanism for this theory is still unclear. To provide insights into the potential mechanism of ″NXTZ″,this study attempts to deeply investigate the mechanism from two representative cardiovascular and cerebrovascular diseases,coronary heart disease（ CHD） and cerebral apoplexy. First,various data resources were integrated to obtain different types of biomedical entities including drugs,targets,pathways and diseases. Then,three different approaches including text mining,biological network and enrichment analysis were utilized to recognize the potential common features between CHD and cerebral apoplexy,and the corresponding functions of drugs which could treat both diseases,thus unveiling the mechanism of NXTZ.
出处
《中国中药杂志》
CAS
CSCD
北大核心
2015年第21期4288-4296,共9页
China Journal of Chinese Materia Medica
基金
国家自然科学基金青年科学基金项目(81303152)
国家自然科学基金重点项目(81330086)
关键词
脑心同治
数据科学
脑中风
冠心病
treating heart and brain diseases with same methods
data science
cerebral apoplexy
coronary heart disease
