摘要
目的:评估薯蓣皂苷元对小鼠的亚慢性毒性作用。方法:采用随机数字表法将80只小鼠分为0(对照)、100、200、400 mg·kg-1共4组,每天灌胃1次,连续给药90天,评估薯蓣皂苷元对小鼠的亚慢性毒性作用。观察指标包括小鼠体质量、毛色、饮食、粪便情况等,检测指标包括血常规分析、血液生化检查和病理学检查。结果:与对照组相比,雄性药物组小鼠体质量略减轻。血液学和病理学检查并无明显异常。结论:薯蓣皂苷元亚慢性毒性无可见不良效应剂量水平大于400 mg·kg-1,口服给药较为安全。
This study was aimed to evaluate the subchronic toxicity of diosgenin in mice. A total of 80 mice were divided into 4 groups, which were 0（control）, 100, 200, and 400 mg·kg-1 by the random number table. Intragastric administration was given once a day for 90 days in the assessment of subchronic toxicity of diosgenin among mice. The observed indexes contained body weight, fur color, diet, feces, and etc. The detected indexes contained blood routine analysis, blood biochemistry and pathological examination. The results showed that compared with the control group, the body weights of mice in the male medication group were slight reduced. There were no significant hematologic and pathologic abnormalities. It was concluded that the subchronic toxicity of diosgenin with no observed adverse effect dose level was more than 400 mg·kg-1. The oral administration was relatively safe.
出处
《世界科学技术-中医药现代化》
2015年第9期1823-1827,共5页
Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology
基金
国家自然科学基金委面上项目(81273986):穿龙薯蓣皂苷对CIA鼠CD4+T细胞亚群平衡的影响及其调控机制研究
负责人:宋鸿儒
关键词
薯蓣皂苷元
穿山龙
亚慢性毒性
无可见不良效应剂量水平
Diosgenin
Rhizoma Dioscreae Nipponicae
subchronic toxicity
no observed adverse effect dose level
