摘要
目的:探究肠内营养粉剂在1岁以下苯丙酮尿症患儿中的应用效果。方法:120例年龄<1岁的苯丙酮尿症患儿持续32周喂养肠内营养粉剂,20 g/kg,qd。比较治疗前、治疗8周、治疗32周时患儿的苯丙氨酸水平、身高、体质量、头围、智商水平、各项营养指标变化和不良反应情况。结果:治疗8、32周时,患儿的苯丙氨酸水平较治疗前逐渐降低,身高、体质量、头围较治疗前逐渐增长,差异有统计学意义(P<0.05)。患儿的智商水平治疗8周时优于治疗前,治疗32周时优于治疗8周时,差异均具有统计学意义(P<0.05)。治疗8、32周时,患儿各项营养指标均较治疗前显著改善,且治疗32周时患儿的丙氨酸转氨酶(ALT)、白蛋白(Alb)和血清总蛋白(TP)水平显著优于治疗8周时,差异有统计学意义(P<0.05)。治疗32周时,患儿的尿素氮(BUN)、总胆红素(TBil)、前白蛋白(Pa)水平与治疗8周时比较差异均无统计学意义(P>0.05)。有66例患儿在治疗中发生181次不良反应,主要为10次腹泻和126次上呼吸道感染,其中1例患儿出现中度胃肠炎,经对症处理后均恢复正常。结论:给予1岁以下苯丙酮尿症患儿肠内营养粉剂,能够有效控制患儿的苯丙氨酸水平,避免其智商水平的下降,改善其营养状况,进而满足患儿正常发育生长的营养需求,且具有较好的安全性和耐受性。
OBJECTIVE：To explore the effects of enteral nutrition powder in children with phenylketonuria（PKU）under one year. METHODS：120 PKU children under one year were selected and given enteral nutrition powder（20 g/kg,qd）for consecutive32 weeks. The level of benzene,height,weight,head circumference,IQ level,nutrition indicators and ADR were compared before treatment,8 weeks after treatment,32 weeks after treatment. RESULTS：8 and 32 weeks after treatment,the level of benzene decreased gradually,and height,weight and head circumference increased gradually,with statistical significance（P〈0.05）. IQ level of children after 8 weeks treatment were better than before,and those of children after 32 weeks treatment were better than after8 weeks treatment,with statistical significance（P〈0.05）. 8 and 32 weeks after treatment,nutrition indicators were improved significantly,compared with before treatment;ALT,Alb and TP levels 32 weeks after treatment were significantly better than 8weeks after treatment,with statistical significance（P〈0.05）.There was no statistically significant difference in BUN,TBil and Pa levels between 32 weeks after treatment and 8 weeks after treatment（P〉0.05）. 66 cases suffered from 181 times of ADR,mainly including 10 times diarrhea and 126 times upper respiratory tract infection,among which one children developed moderate gastroenteritis. They were all recovered after symptomatic treatment. CONCLUSIONS：For PKU children under one year,enteral nutrition powder can effectively control the phenylalanine levels,prevent the decrease of IQ and improve the nutritional status so as to meet the normal growth and development of children nutritional requirements,with better safety and tolerance.
出处
《中国药房》
CAS
北大核心
2015年第35期4968-4970,共3页
China Pharmacy
