摘要
目的对比观察期为12周的氯沙坦钾与辛伐他汀联合治疗对糖尿病腹膜透析患者氧化应激指标的影响。方法收集2型糖尿病合并糖尿病肾病终末期新进入持续不卧床腹膜透析(CAPD)的患者80例,随机分为2组:对照组40例腹膜透析及常规治疗;治疗组40例在对照组基础上给予氯沙坦钾50 mg,1次/d,辛伐他汀分散片20mg,每晚1次。对比2组透析前及透析12周后糖化血红蛋白(HbAlC)、胰岛素用量、超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-PX)、丙二醛(MDA)、同型半胱氨酸(Hcy)等指标变化。结果 2组HbA1C治疗前后及组间差异均无统计学意义(P>0.05),2组在CAPD治疗后所用胰岛素剂量均较透析前增加,其中治疗组低于对照组(P<0.05);透析后,治疗组SOD、GSH-PX表达水平均高于治疗前和对照组,MDA和Hcy均低于治疗前和对照组(P<0.05);对照组GSH-PX水平低于透析前,MDA和Hcy则高于治疗前(P<0.05)。结论氯沙坦钾联合辛伐他汀对糖尿病腹膜透析患者氧化应激指标的改善疗效确切。
Objective To explore the effects of losartan potassium and simvastatin combination therapy on oxidative stress indicators in diabetic patients on peritoneal dialysis through 12 weeks observation. Methods Diabetic patients with end-stage nephropathy （n=80） who were treated with continuous ambulatory peritoneal dialysis were randomly divided into two groups：control group who received routine treatment （n=40）, treatment group who were given losartan potassium 50 mg, once per day and simvastatin 20 mg, once every night （n=40）. HbA1C, Insulin dosage, Oxidative stress indicators（SOD, GSH-PX, MDA and Hcy）were compared between two groups before and after peritoneal dialysis. Results There was no significant difference of HbA1C between the 2 groups before and after treatment（P＆gt;0.05）. The insulin doses increased be？fore dialysis in both groups after CAPD treatment. It is lower in the treatment group than that in the control group （ P〈0.05）. The expression levels of GSH-PX and SOD in treatment group were higher while the expressions of Hcy and MDA were lower after treatment. The expressions of GSH-PX and SOD were higher while the expressions of Hcy and MDA were lower in treat？ment group than those in control group when comparing the same time point（P〈0.05）. GSH-PX expression level was lower while the expressions of MDA and Hcy were higher after dialysis than those before dialysis in control group （ P〈0.05）. Con？clusion Losartan potassium combined with simvastatin treatment can improve curative effect and oxidative stress indicators in diabetic patients on peritoneal dialysis.
出处
《天津医药》
CAS
2015年第12期1453-1455,共3页
Tianjin Medical Journal
关键词
腹膜透析
持续不卧床
糖尿病肾病
氧化性应激
药物疗法
联合
氯沙坦钾
辛伐他汀
peritoneal dialysis,continuous ambulatory
diabetic nephropathies
oxidative stress
drug therapy,combina-tion
Losartan potassium
Simvastatin
