摘要
目的:分析DDR1基因在不同复发倾向肝癌患者中的表达水平和在肝癌临床预后中的价值。方法:将我院40例接受根治性切除术治疗的肝癌患者依据术后复发倾向不同分为早期复发组20例和非早期复发组20例,另选择20例同期健康体检肝组织正常者作为对照组,采用免疫组化法分析各组DDR1基因的表达情况。采用SPSS 11.0软件对结果进行统计学分析。结果:40例肝癌患者和20例肝组织正常者的DDR1阳性表达率分别为65%和10%,组间差异有统计学意义(χ2=31.45,P<0.05);早期复发组和非早期复发组患者的阳性表达率分别为85%和45%,组间差异有统计学意义(χ2=11.32,P<0.05);DDR1基因的阳性表达率和患者年龄、性别、肿瘤直径没有直接关系(P>0.05)。结论:DDR1基因表达和肝癌患者术后复发倾向关系密切,阳性表达率越高,术后肝癌早期复发和淋巴结转移的可能性越大。因此,DDR1基因表达水平的高低可以作为预后判断的一项重要指标。
Objective： To analyze the difference of DDR1 gene expression level in liver cancer patients with different recurrence tendency and its value in clinical prognosis. Methods： 40 cases of liver cancer who received the curative resection,based on different recurrence tendency,were divided into early recurrence group（ 20 cases）and non-early recurrence group（ 20 cases）,also chose 20 cases with healthy liver tissue as control group. The expression of DDR1 gene was detected by immunohistochemistry. The results were analyzed by SPSS 11. 0software. Results： The positive expression rate of patients with liver cancer and people with healthy liver cancer were 65% and 10%,respectively,and the difference was significant（ χ^2= 31. 45,P〈0. 05）. The positive expression rate of early recurrence group and non-early recurrence group were 85% and 45%,respectively,and the difference was significant（ χ^2= 11. 32,P〈0. 05）. The age,sex and diameter of tumor had no direct relationship with DDR1 gene expression（ P〉0. 05）. Conclusion： DDR1 gene expression has close relationship with recurrence tendency of cancer liver patients,the higher of DDR1 gene expression rate,the greater the likelihood of early recurrence and lymphatic metastasis. The detection of DDR1 gene may act as an important index of prognosis.
出处
《现代医学》
2015年第8期1015-1018,共4页
Modern Medical Journal
关键词
DDR1基因
肝癌
早期复发
阳性表达率
DDR1 gene
liver cancer
early recurrence
positive expression rate
