摘要
目的:探讨经导管动脉栓塞术(TAE)治疗不同原因所致肝破裂出血的临床疗效及不良反应,并分析其相关性。方法:对经TAE治疗的30例原发性肝癌自发性肝破裂出血和30例外伤性肝破裂出血患者进行回顾性分析,采用卡方检验和Logistic回归分析比较不同肝破裂病因、出血程度等因素对疗效和不良反应的影响。结果:TAE对原发性肝癌自发性肝破裂止血有效率达96.7%,对外伤性肝破裂为90%;轻和中度肝破裂出血的TAE止血有效率显著高于重度患者(χ2=6.29,P=0.04);TAE的不良反应迷走神经反应征(χ2=8.28,P=0.02)和肝衰竭(χ2=11.03,P<0.01)在重度肝破裂出血患者中的发生率显著高于轻中度者。结论:TAE的止血有效率和不良反应发生率与肝破裂程度有关,对原发性肝癌自发性肝破裂出血和外伤性肝破裂出血治疗均安全有效。
Objective： To evaluate the clinical efficacy and adverse of different liver rupture by transcatheter arterial embolization（ TAE）,and analyze their relevance. Methods： 30 hepatic rupture patients with hepatocellular carcinoma and 30 patients with traumatic rupture were treated by TAE,chi-square test and Logistic regression analysis were used to detect the impactions of different causes,bleeding and other factors on the efficacy and adverse reactions. Results： The effective rate of hepatocellular carcinoma hepatic rupture by TAE was 96. 7%,traumatic rupture is 90%; the effectiveness by TAE in mild and moderate hepatic rupture was significantly higher than severe patients（ χ^2= 6. 29,P = 0. 04）; the adverse of TAE,vagal response syndrome（ χ^2= 8. 28,P = 0. 02）and liver failure（ χ^2= 11. 03, P 〈0. 01） was significantly serious in severe patients. Conclusion： The effectiveness and incidence of adverse reactions of TAE are related to the degrees of liver rupture; and TAE is a safety and effective method for treat hepatocellular carcinoma spontaneous liver rupture and traumatic rupture.
出处
《现代医学》
2015年第8期956-960,共5页
Modern Medical Journal
关键词
经导管动脉栓塞术
肝破裂出血
疗效
不良反应
transcatheter arterial embolization
liver rupture
efficacy
adverse reaction
