摘要
目的探讨术中自体洗涤红细胞回输与自体等容性血液稀释技术对体外循环手术患者红细胞、凝血及肾功能的影响。方法选取2011年1月至2014年1月在曲靖市第一人民医院麻醉科行体外循环下心脏手术患者60例,采用随机数字表法分为两组,各30例。观察组采用自体洗涤红细胞回输,对照组采用等容性血液稀释技术进行回输,比较两组患者术后红细胞、血红蛋白计数,凝血功能、血小板a颗粒膜蛋白及血尿素氮、肌酐等水平,并进行统计学分析。结果观察组术后红细胞计数、血红蛋白均高于对照组[(5.7±0.7)×10^(12)/L比(4.3±0.3)×10^(12)/L,(157.2±12.0)g/L比(142.4±9.0)g/L,P<0.05];观察组凝血时间、纤维蛋白原、血小板a颗粒膜蛋白、血尿素氮、血肌酐均低于对照组[(10.3±0.3)s比(11.5±0.6)s,(2.6±0.7)g/L比(2.8±0.3)g/L,(12.7±1.2)ng/L比(14.2±1.2)ng/L,(3.6±0.4)mmol/L比(4.0±0.5)mmol/L,(116.3±9.8)mmol/L比(184.2±12.3)mmol/L,P<0.05]。结论自体洗涤红细胞回输技术在体外循环手术中可有效补充血容量,保护凝血功能和肾功能,值得临床推广。
Objective To investigate the influence of intraoperative autologous transfusion of washed red blood ceils and autologous normovolemie hemodilution on red blood cells, blood coagulation and renal function of patients undergoing extracorporeal circulation operation. Methods Total of 60 eases with heart opera- tion under eardiopulmonary bypass were chosen in the department of anesthesiology in Qujing First People＇s Hospital from Jan. 2011 to Jan. 2014, according to random number table method ,they were divided into two groups,30 cases each. Autologous washed red blood cell transfusion （observation group） and isovolumetrie blood dilution teehnique（ control group ） were infused, and the red blood cell, hemoglobin （Hb） , blood coagulation,platelet a granule membrane protein and blood urea nitrogen （BUN） , ereatinine （Cr） levels were compared between the two groups after operation. Results The red cell count and Hi） of the observation group were higher than that of the control group[ （5.7 ±0. 7 ） × 10^12/L vs （4. 3 ±0. 3 ） × 10^12/L, （ 157.2 ± 12. 0） g/L vs （ 142.4 ±9.0） g/L,P 〈0.05 ] ,coagulation time,fibrinogen,platelet a granule membrane protein, BUN, blood Cr in the observation group were lower than those in the control group [ （ 10. 3±0. 3 ） s vs （11.5±0.6） s,（2.6±0.7） g/L vs （2.8 ±0.3） g/L,（12.7±1.2） ng/L vs （14.2 ＋1.2） ng/L, （3.6±0. 4） mmol/L vs （4.0 ±0. 5） mmol/L, （ 116. 3±9.8） mmol/L vs （ 184.2± 12. 3） mmot/L,P 〈 0. 05]. Conclusion Autologous washed red blood cell transfusion can effectively supplement the blood vol- ume in extracorporeal circulation operation, protect of blood coagulation and renal function, thus is worthy of clinical application.
出处
《医学综述》
2015年第23期4414-4416,共3页
Medical Recapitulate
关键词
自体血回输
洗涤红细胞
体外循环
Autologous blood transfusion
Washed red blood ceils
Extracorporeal circulation
