摘要
HCV是导致急性和慢性肝炎、肝硬化、肝细胞癌的主要原因之一。实验室诊断是确诊HCV感染的必要条件。HCV感染的实验室病原学诊断包括抗原、抗体检测和HCV RNA定量检测。血清HCV RNA定量检测是确定HCV现症感染的唯一实验室指标,在决定治疗时间和治疗方案选择,以及抗病毒疗效评价方面起非常重要的作用。阐述了慢性HCV感染实验室筛查的目标人群、检测方法及临床意义等,以便及时的诊断和有效的治疗慢性HCV感染。
Hepatitis C virus （HCV） is one of the major causes of acute and chronic hepatitis, liver cirrhosis, and hepatocellular carcinoma. Laboratory diagnosis is essential for the diagnosis of HCV infection. Laboratory etiological diagnosis of chronic HCV infection includes HCV antigen and antibody detection and quantitative detection of HCV RNA. Quantitative detection of serum HCV RNA is the only laboratory diagnosis index for current HCV infection and plays a very important role in determination of treatment time, selection of treatment regimens, and evaluation of therapeutic effect of antiviral treatment. This paper elaborates on the target population, detection methods, and clinical significance in laboratory screening for chronic HCV infection, so as to provide timely diagnosis and effective treatment of chronic HCV infection.
出处
《临床肝胆病杂志》
CAS
2015年第11期1817-1819,共3页
Journal of Clinical Hepatology
基金
国家"十二五"科技重大专项项目(2012ZX10002003)
辽宁省科学技术计划项目(2014225020)
辽宁省临床能力建设项目(LNCCC-A02-2014)
关键词
肝炎病毒属
实验室技术和方法
诊断
hepacivirus
laboratory techniques and procedures
diagnosis
