摘要
目的分析高同型半胱氨酸血症（HHcy）与老年痴呆（AD）发病的相关性。方法选取2010年4月至2013年5月该院收治的痴呆老年患者100例,并据患者病情分为老年痴呆（AD）组和血管性痴呆（VD）组,另选取健康老年人50例为对照组,检测治疗前后3组同型半胱氨酸（Hcy）水平,分析Hcy水平与AD发病的相关性。结果 AD、VD组患者Hcy水平均高于对照组,治疗后Hcy水平均下降,差异均有统计学意义（P〈0.05）;治疗后AD、VD组患者简易精神状态量表（MMSE）评分均升高,且AD组患者日常生活能力量表（ADL）评分降低,差异均有统计学意义（P〈0.05）;重度AD患者Hcy水平高于轻度AD患者,差异有统计学意义（P〈0.05）;AD的优势比（OR）值为4.7,95%置信区间（CI）为1.76~7.09;AD患者Hcy水平与MMSE评分呈明显负相关（轻、中、重度AD相关系数r分别为-0.32、-0.40、-0.27,P〈0.05）。结论 HHcy是导致AD患者发病的独立危险因素,应加强对高Hcy水平的关注,以防治老年痴呆。
Objective To analyze the relationship between hyperhomocystinemia（HHcy）and occurrence of Alzheimer disease（AD）.Methods A total of 100 cases of elderly patients with dementia were collected,from April 2010 to May 2013,and divided into AD group and vascular dementia（VD）group according to patients′condition.Other 50 cases of healthy elderly individuals were collected in the control group.Levels of homocysteine（Hcy）were detected,and the relationship between level of Hcy and occurrence of AD was analysed.Results Levels of Hcy in the AD group and VD group were higher than that in the control group,and were decreased after treatment,there were statistically significant differences（P〈0.05）.After treatment,the scores of mini-mental state examination（MMSE）in the AD group and VD group both were increased,and the score of activity of daily living scale（ADL）was decreased in the AD group,there were statistically significant differences（P〈0.05）.The level of Hcy in mild AD patients was lower than that in severe AD patients,the difference was statistically significant（P〈0.05）.The AD odds ratio（OR）was 4.7,and 95% confidence interval（CI）was 1.76-7.09.The level of Hcy in patients with AD was significantly negatively correlated with score of MMSE,the coefficient value（r）was-0.32,-0.40 and-0.27 in mild,moderate and severe AD（P〈0.05）.ConclusionHHcy is an independent risk factor for the onset of AD,so attention should be paid on high Hcy level,in order to prevent AD.
出处
《国际检验医学杂志》
CAS
2015年第23期3400-3402,共3页
International Journal of Laboratory Medicine
