摘要
目的:研究法莫替丁治疗儿童消化性溃疡的临床疗效并对其成本-效益进行评价,探讨其临床实用性。方法:选取2013年1月至2013年12月我院治疗的消化性溃疡患儿156例,随机分为试验组和对照组各78例,试验组予口服法莫替丁治疗,对照组予口服奥美拉唑钠肠溶胶囊。观察两组患儿治疗后的临床疗效;记录两组患儿治疗两个疗程后总费用及药物成本费用,并对两组患儿治疗成本-效益进行比较分析;观察不良反应发生情况。结果:两组患儿经治疗3周后,试验组和对照组总有效率分别为79.5%和71.8%,两组比较差异无统计学意义(P>0.05);两组患儿治疗后的总治疗费用比较,试验组明显低于对照组;两组药物成本-效益比较差异有统计学意义(P<0.05)。两组不良反应发生情况比较差异无统计学意义(P>0.05)。结论:法莫替丁治疗儿童消化性溃疡,疗效显著,且成本低,适合在基层医院长期推广应用。
Objective： To study the clinical efficacy of famotidine in the treatment of children with peptic ulcer and to evaluate its costbenefit,to explore its clinical applicability. Methods： One hundred and fifty six cases of peptic ulcer children were selected from January 2013 to December 2013 in our hospital,all children were randomly divided into experimental group（ 78 cases） and control group（ 78 cases）. The experimental group was treated with famotidine,while the control group was received oral aomeiprazole sodium enteric-coated capsules treatment. Clinical effects of two groups were observed after treatment,the total costs and drug costs of the two groups after two courses of treatment were recorded,and the treatment cost-benefit of two groups were analyzed,and the adverse reactions occurred during the treatment were observed. Results： After 3 weeks＇ treatment,the total effective rate of the experimental group was 79. 5%,and the control group was 71. 8%,and the difference was not statistically significant（ P〈0. 05）. The total cost of the experimental group was significantly lower than the control group,the treatment cost-benefit of two groups had significant difference（ P〈0. 05）. The incidence of adverse reactions of two groups had no significant difference（ P〉0. 05）. Conclusion： The efficacy of Famotidine in the treatment of children with peptic ulcers is significantly,and has low cost,which is suitable for promotion and application in primary hospitals.
出处
《儿科药学杂志》
CAS
2015年第12期25-27,共3页
Journal of Pediatric Pharmacy
