摘要
目的:对我国已发表的关于药学监护与糖尿病文献进行系统评价。方法:系统分析基于中国期刊全文数据库(CNKI),维普和万方3个数据库,以"药学监护"与"糖尿病"及"药学服务"与"糖尿病"为关键词组合,检索1990年1月-2015年5月所有相关文献,根据纳入及排除标准,确定入选文献。进行评价指标和纳入文献质量评价分析。结果:共检索到文献810篇,符合纳入标准的36篇;文献报道集中于医院药学监护和少量社区药学监护;样本数量由13例到432例;年龄跨度范围从13岁至91岁。药学监护干预时间超过6个月的有15篇(占41.6%);绝大部分文献中设计有随机对照试验,但Jadad评分值较低;血糖控制率,用药依从性,不良反应发生率作为主要评价指标,干预组均显著性优于对照组。结论:系统评价研究显示药学监护对糖尿病的治疗干预效果起到了积极作用,但大部分试验设计存在方法学缺陷。因此,我国药学监护对糖尿病干预研究设计应更科学合理才能充分体现药学监护的指导意义。
OBJECTIVE To describe and appraise published researches on management of patients diagnosed with diabetes mellitus under pharmaceutical care in China. METHODS CNKI, CQVIP and Wanfang databases from January 1990 to May 2015 were searched using keywords ＂pharmaceutical care,＂ and ＂diabetes＂. Further abstracted data were collected including de- scriptive characteristics, research design and outcomes, and study limitations. RESULTS Literature search identified 811） arti des, of which 36 satisfied the inclusion criteria. Most studies were in hospital settings and few in community, with sample si zes ranged of 13 to 432 patients and age of 13 to 91 years old. Fifteen studies （41.60/oo） reported a follow up period of more than 6 - month. Most studies were randomized clinical trials but generally had low-quality method scores as per Jadad scale. Glyce- mic control rate, medication adherence and ADR rate were the most common outcome measures. As expected, these outcomes were positively impacted by pharmaceutical intervention. CONCLUSION Systematic review indicates that pharmaceutical care has positive effects and improvements on diabetes mellitus therapy. However, most studies have defections in study design in methodology. Therefore, pharmaceutical care only has guiding significance when study design on diabetes intervention is more scientific and reasonable.
出处
《中国医院药学杂志》
CAS
CSCD
北大核心
2015年第22期2052-2057,共6页
Chinese Journal of Hospital Pharmacy
关键词
药学监护
糖尿病
系统评价
pharmaceutical care
diabetes mellitus
systematic reviews
