摘要
IKKε作为新发现的IKK相关激酶,通过介导非经典的NF-κB和IRF信号通路,在调控炎性反应、天然免疫、癌症形成等方面都具有重要的作用。同时,IKKε在代谢性疾病中的作用也逐渐被认识。IKKε与肥胖、2型糖尿病、非酒精性脂肪性肝病等密切相关,其作用机制主要包括促进组织炎性反应、加重胰岛素抵抗、影响能量代谢及脂肪因子分泌等方面。
IKKε is a new IκB kinase（IKK）-related kinases with plays a vital role in regulating inflammation, in- nate immune response and oncogenesis through the activation of non-canonical NF-κB and IRF signaling cascades. Meanwhile, the role involved in the pathophysiology of metabolic diseases have been found. IKKε have been close- ly linked to obesity, type 2 diabetes （T2DM）and non-alcoholic fatty liver disease （NAFLD）through the mechanisms including producing inflammation, aggravating insulin resistance and effecting energy expenditure as well as andipo-kines secretion.
出处
《基础医学与临床》
CSCD
2015年第12期1686-1690,共5页
Basic and Clinical Medicine
基金
三峡大学培优基金(2015PY057)
关键词
IKKε
2型糖尿病
非酒精性脂肪肝
IKKε
type 2 diabetes mellitus
non-alcoholic fatty liver disease
