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离子液体中4-芳基-2,7,7-三甲基-5-氧代-N-苯基-1,4,5,6,7,8-六氢化喹啉-3-甲酰胺衍生物的绿色4组分合成 被引量：1

Green synthesis of 4-aryl-2,7,7-trimethyl-5-oxo-N-phenyl-1,4,5,6,7,8-hexahydroquinoline-3-carboxamide derivatives in ionic liquids via four-component reaction
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摘要 以4组分的芳醛、达米酮、醋酸铵和3-氧代-N-苯基丁酰胺为原料,离子液体[BMIm]Br为绿色介质,80℃反应获得一系列4-芳基-2,7,7-三甲基-5-氧代-N-苯基-1,4,5,6,7,8-六氢化喹啉-3-甲酰胺衍生物.通过氢谱、红外光谱和高分辨质谱表征了产物的结构.该反应具有产率高、多组分一步反应、环境友好和条件温和等优点. Using aldehyde,dimedone,ammonium acetate and 3-oxo-N-phenylbutanamide as four-component reactants,a series of 4-aryl-2,7,7-trimethyl-5-oxo-N-phenyl-1,4,5,6,7,8-hexahydroquinoline-3-carboxamide derivatives were obtained in ionic liquids of[BMIm]Br at 80℃.Their structures are characterized by 1 HNMR,IR and HRMS.The procedure has the advantages of high yields,four-component in one pot reaction,milder reaction conditions and environmentally benign.
作者 陈冬生 张梅梅 王香善
机构地区 南京医科大学康达学院 江苏师范大学化学化工学院
出处 《江苏师范大学学报（自然科学版）》 CAS 2015年第4期57-61,共5页 Journal of Jiangsu Normal University：Natural Science Edition
基金 江苏省高校重大基础研究课题(14KJA15004)
关键词 达米酮 喹啉 离子液体 4组分 合成 dimedone quinoline ionic liquid four-component synthesis
分类号 O626.4 [理学—有机化学]
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参考文献16

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二级参考文献38

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江苏师范大学学报（自然科学版）
2015年 第4期

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