摘要
目的探讨乌鲁木齐肿瘤患者红细胞血型不规则抗体的检出率与分布特征,为该地区肿瘤患者疑难输血的安全提供帮助。方法收集新疆医科大学附属肿瘤医院住院患者血液标本,采用微柱凝胶免疫技术对各类肿瘤患者进行不规则抗体筛查,采用盐水法、聚凝胺法和抗球蛋白法对抗体筛查阳性的病例进行特异性抗体及红细胞血型基因的鉴定,并进行分析总结。结果 19 903例肿瘤患者共筛查出不规则抗体阳性患者166例,阳性率为0.83%,其中女性122例,男性44例,女性明显多于男性(P<0.05)。汉族98例,维吾尔族62例,回族4例,哈萨克族2例,汉族患者不规则抗体阳性率高于维吾尔族患者(P<0.05)。166例不规则抗体阳性患者中Lewis系统抗体58例(34.94%),Rh系统抗体45例(27.10%),MN系统抗体33例(19.9%),自身抗体14例(8.4%),Kidd系统抗体2例(1.2%),P系统抗体2例(1.2%),冷抗体10例(6.0%),未确定抗体类型2例(1.2%)。结论乌鲁木齐为多民族聚居地区,对新疆医科大学附属肿瘤医院住院患者进行不规则抗体的检测及鉴定,对于保障临床用血,降低溶血性输血反应的发生有重要意义。
Objective This study focused on irregular antibodies positive rate among tumor patients and distribution feature of the irregular antibodies. Methods The patients ＇ irregular antibodies were screened with micro-column gel card technique,and the type of the antibody was determined by saline method,polybrene method and antiglobulin method. Results Among 19 903 serum samples of tumor patients,irregular antibodies were observed in 166 patients（ the rate of positive was 0. 83%）,122 female and 44 male,the positive rate of female was significantly more than the male（ P〈0. 05）; and in which 98 cases of Han,62 cases of Uygur,four cases Hui,two cases of Kazak,the positive rate of Han is significantly more than Uygur（ P〈0. 05）; and in which 34. 9% with antibodies in Lewis system,27. 1%in Rh system,19. 9% in MN system,8. 4% in autoantibody system,1. 2% in Kidd system,1. 2 in P system,6. 0% in cold antibody,two cases of undetermined type of antibody. Conclusion Urumqi is a multi-ethnic region. The screening of irregular antibodies in tumor patients of Xinjiang medical University Tumor Hospital helps to guarantee the safety of blood transfusion in operation and reduce the possibility of hemolytic transfusion reaction.
出处
《新疆医科大学学报》
CAS
2015年第12期1539-1541,共3页
Journal of Xinjiang Medical University
基金
新疆医科大学附属肿瘤医院创新基金(2014-06)
关键词
肿瘤
不规则抗体
输血
tumor
irregular antibodies
blood transfusion
