摘要
目的:对老年骨质疏松合并高血压患者与血压变异性进行相关性分析及机制初步探讨。方法:选择老年高血压患者189例,根据骨质疏松诊断标准分为骨量正常组56例,骨量降低组70例,骨质疏松组63例,行24 h动态血压,检测白介素-6(IL-6),比较各组IL-6、血压变异性的差异。结果 :(1)3组IL-6、血压变异性比较差异有统计学意义(P<0.05)。(2)血压变异性与各部位骨密度成负相关(P<0.05)。(3)IL-6与血压变异性成正相关(P<0.05),与各部位骨密度成负相关(P<0.01)。(4)不同性别间IL-6比较差异有统计学意义(P<0.01)。结论:老年骨质疏松合并高血压患者与血压变异性密切相关,随骨量减少,IL-6、血压变异性水平升高;IL-6与血压变异性在骨质疏松的发生过程中可能起到协同作用,且IL-6可能是绝经女性发生骨质疏松的危险因素。
Objective To explore the association of osteoporosis with blood pressure variability in elderly patients with hypertension complicated by osteoporosis, as well as its mechanisms. Methods A total of 189 elderly patients with hypertension were selected. According to the diagnostic criteria for osteoporosis, the patients were divided into three groups. 24-hour ambulatory blood pressure and IL-6 were detected in all the patients, and then compared among different groups. Results For the three group, there were statistical differences in levels of IL-6 and blood pressure variability （P 〈 0.05）. Blood pressure variability was negatively correlated with BMD （P 〈 0.05）. 3. IL-6 was positively related with blood pressure variability （P 〈 0.05）, but had a negative correlation with BMD （P 〈 0.01 ）. IL-6 had significant statistical differences among different sexes （P 〈 0.01）. Conclusions Osteoporosis is closely associated with blood pressure variability in the elderly patients. IL-6 and blood pressure variability may play a synergistic role in the process of osteoporosis; and IL-6 may be a risk factor for postmenopausal osteoporosis in women.
出处
《实用医学杂志》
CAS
北大核心
2015年第22期3653-3656,共4页
The Journal of Practical Medicine
基金
国家临床重点专科建设项目资助
关键词
骨质疏松
老年人
高血压
血压变异性
IL-6
Osteoporosis
The elderly
Hypertension
Blood pressure variability
IL-6
