摘要
目的探讨痰热清治疗放射性肺损伤疗效及相关细胞因子的影响。方法将2008年2月至2013年6月就诊于河北省人民医院，经病理证实为肺癌并接受胸部放疗发生放射性肺损伤的患者56例随机分为治疗组和对照组，每组28例。2组均采用常规抗生素治疗及激素治疗，治疗组在上述基础上使用痰热清注射液30m1＋0．9％氯化钠注射液250ml，静脉滴注，每日1次，连用30d。治疗前后进行肺损伤评级、CT疗效评价、转化生长因子β1（TGF-β1）、IL-6、肿瘤坏死因子a（TNF—a）浓度测定。结果2组治疗前肺损伤评级差异均无统计学意义（P值均〉O．05），治疗后两组0级肺损伤差异有统计学意义（z。=5．567，P=0．032）；治疗后CT显示治疗组有效率高于对照组（x2=4．995，P=0．025）；治疗后治疗组血浆TGF-β、TNF-a较对照组降低（P值均〈O．05），治疗组血浆IL-6水平亦有降低，但差异无统计学意义（P〉O．05）。结论痰热清能降低放射性肺损伤患者血浆TGF-β、TNF-a表达，对治疗急性放射性肺损伤具有一定疗效。
Objective To explore the efficacy of Tanreqing treatment on radiation-induced lung injury and the effects on relative cytokines. Methods 56 patients who received treatment in Hebei Province People＇s Hospital from February 2008 to June 2013 and were pathologically confirmed to be lung cancer and eventually got radiation-induced lung injury by chest radiation therapy were randomly divided into treatment group and control group, each group had 28 cases. Both groups were treated with routine antibiotics therapy and hormones therapy. Besides, the treatment group was injected with 30 ml Tanreqing （250 ml 0.9%sodium chloride injection added） by intravenous injection once a day for 30 days. In pretherapy and post-treatment, lung injury rating, CT efficacy evaluation, concentrations of transforming growth factor β1 （TGF-β1） ,interleukin-6 （IL-6） and tumor necrosis factor-a （TNF-a） were measured. Results Belore treatment,there was no signiiicam difference in lung injury raking between two groups （ P 〈0.05）. However, there was significant difference in lung injury rating 0 after treatment between two groups （ X2 =5. 567, P =0. 032）. After treatment,CT showed that the effective rate in treatment group was higher than that in control group （X2= 4. 995, P = 0. 025）. In addition, the levels of TGF-β1 and TNF-a after treatment in treatment group decreased compared to the control group （all P 〈0.05）. By contrast,the difference in the level of IL-6 was not statistically significant （ P 〉0.05） ,although IL-6 ievd in treatment group went down relatively. Conclusions Tanreqing can reduce the expressions of plasma TGF-β1 and TNF-a in patients with radiation-induced lung injury, which has a certain effect on acute radiation lung injury.
出处
《国际呼吸杂志》
2015年第22期1711-1714,共4页
International Journal of Respiration
