摘要
目的观察皮质下缺血性血管病中轻度认知损害患者的危险因素,随访分析危险因素对皮质下血管性轻度认知损害(subcortical vascular mild cognitive impairment,SVMCI)的影响。方法根据Erkinjuntti提出的核磁共振诊断标准及神经心理学测验筛选139例SVMCI患者,记录相关危险因素,随访1年后评估患者认知功能状态,分为三组,即皮质下缺血性血管性痴呆组,SVMCI组和皮质下缺血性血管病认知功能正常组。结果基线水平观察,三组患者的年龄、高血压病、受教育年限、2型糖尿病、高同型半胱氨酸血症差异有统计学意义(均有P<0.05),多元回归分析发现受教育年限是认知损害的保护因素,合并有高血压病、糖尿病、高同型半胱氨酸血症的SVMCI患者更易出现认知损害加重(均有P<0.05)。结论积极控制高血压病、糖尿病、高同型半胱氨酸血症等血管危险因素对预防SVMCI转变为痴呆具有重要意义。
Objective To investigate the risk factor of cognitive impairment in patients of mild cognitive impaiment with subcortieal ischemie vascular disease, and to discuss the influence of the risk factor on subcortieal vascular mild cognitive impairment （SVMCI） by follow-up analysis. Methods We enrolled one hundred and thirty-nine SVMCI patients according to magnetic resonance imaging diagnosis criteria proposed by Erkinjuntti and based on neuropsychologieal assessment,then recorded their associated risk factors, signs and symptoms. After one year follow-up, cognitive function was assessed in the patients. The patients were divided into three groups according to cognitive status of the patients after one year： subcortical vascular dementia group,SVMCI group and subcortical ischemic vascular disease with no cognitive impairment group. Results At the baseline level, a statistical significance （ all P 〈 0. 05 ） was seen in age, education time, hypertension, type 2 diabetes mellitus and high homocysteine hematic disease among the three groups of patients. The education time was the protective factor of cognitive impairment and those with hypertension, type 2 diabetes and high homocysteine mellitus had more risk of cognitive impairment through multiple regression analysis （ all P 〈 0. 05 ）. Conclusions The prevention of SVMCI into dementia depends on control of the vascular risk factors such as hypertension, diabetes and high homocysteine.
出处
《中华疾病控制杂志》
CAS
CSCD
北大核心
2015年第10期1026-1029,共4页
Chinese Journal of Disease Control & Prevention
基金
安徽省教育厅自然科学重点基金(KJ2011A170)
关键词
血管
危险因素
流行病学研究
Blood vessels
Risk factors
Epidemiologic studies
