摘要
原发性肝内胆管癌又称肝胆管细胞癌,是起源于肝内胆管上皮细胞的一种相对少见的恶性肿瘤,在原发性肝脏恶性肿瘤中仅次于肝细胞癌,流行病学研究显示其发病率有逐渐增高趋势.外科手术治疗是唯一能够获得根治的方法,目前仍缺乏同一单位的大样本临床研究.由于无特异性临床表现,本病早期诊断不易,手术切除率低,临床死亡率较高,预后较差.随着医学影像学及病理诊断技术的提高,早期诊断率增加,本病的总体生存率有所提高,包括非手术治疗在内的综合治疗措施在改善预后中的作用越来越重要.本文综述近年来关于肝内胆管癌的治疗进展,分析其治疗现状,以更好的指导临床实践.
Primary intrahepatic cholangiocarcinoma（ICC）is a rare malignancy arising from intrahepatic biliary epithelial cells and is also defined as cholangiohepatoma.It is the second most common primary liver malignancy after hepatocellular carcinoma.Epidemiologic research shows that the incidence rate of ICC has increased in recent years.Till now,surgical resection remains the only effective treatment to cure the disease,but single-center largesample clinical trials are still limited.Early diagnosis of ICC is difficult due to the lack of specific clinical manifestations.The rate of resection is low,while the mortality is high and the prognosis is poor.With the development of medical imaging and pathological diagnosis technology,the early diagnosis and overall survival rates are increasing.Comprehensive therapy including non-surgical treatment plays a more and more important role in improving the prognosis.The aim of this study is to review the advances in the diagnosis and treatment of ICC in recent years.
出处
《世界华人消化杂志》
CAS
2015年第31期4939-4945,共7页
World Chinese Journal of Digestology
关键词
肝内胆管癌
诊断
治疗
Intrahepatic cholangiocarcinoma
Diagnosis
Treatment
