摘要
目的:分析乳腺癌术后化疗常见不良反应的临床特点.方法:选取我院2011-01/2014-01收治的经手术治疗后存在浸润性乳腺癌的68例患者,按照随机数表法分为观察组和对照组.观察组患者采用AC→T方案化疗,对照组采用TAC方案化疗.比较两组患者化疗前1d与化疗后7d免疫功能、血象及细胞因子水平的变化.观察两组患者化疗后的不良反应及其临床特点.结果:化疗后,观察组患者的CD4^+(43.22±2.76)%、CD8^+(42.45±4.32)%、CD4^+/CD8^+(1.96±0.35)水平明显高于对照组(P<0.05).观察组患者的免疫球蛋白IgA、IgG、IgM水平分别为(1.25±0.11)g/L、(8.21±1.22)g/L、(1.24±0.21)g/L明显低于对照组(P<0.05).观察组患者的PLT、WBC、IL-4、IL-10水平分别为(175±24)×109/L、(8.43±2.42)×109/L、(46.32±4.22)U/mL、(34.21±4.21)U/mL,明显高于对照组.观察组患者的中性粒细胞减少率与减少性的中性粒细胞发热的不良反应率分别为44.12%、26.47%,明显低于对照组(P<0.05),但两组患者在水钠潴留、外周神经毒性、皮肤指甲改变及过敏等不良反应方面比较,差异无统计学意义(P>0.05).结论:乳腺癌术后患者采取不同化疗方案均存在不良反应,然而大多数为Ⅲ度以下的不良反应,均能耐受,予以有效处理后,不良反应有所好转.
AIM： To analyze the clinical characteristics of common adverse reactions of breast cancer after chemotherapy. METHODS： A total of 68 cases of patients with invasive breast cancer after operation, admitted into our hospital from January 2011 to January 2014, were randomly divided into observation group and control group. The observation group received AC→T chemotherapy, while, the control group performed TAC chemo- therapy. The immune function, blood and cytokine level changes in 1 day before chemotherapy 7 days after chemotherapy were compared. At the same time, the adverse reactions and clinical characteristics of the two groups of patients after chemotherapy were observed. RESULTS： After chemotherapy, the level of CD4＋[ （43.22±2.76）%], CD8＋[（42.45±4.32）%], CD4＋/ CDS＋[ （1.96±0.35）] in the observation group were significantly higher than that of the control group （P〈0.05）. IgA, IgG, IgM levels of the observation group were respectively （ 1.25±0.11 ） g/L, （8.21±1.22） g/L, （1.24±0.21） g/L, which were signifieantly lower than those of the eontrol group （P〈0.05）. And the level of PLT, WBC, IL-4, IL-10 in observation group were （175±24）× 10^9/L, （8.43±2.42）×10^9/L, （46.32±4.22） U/mL, （34.21±4.21） U/mL, which were significantly higher than the control group. The rate of neutropenia and fever adverse reaction of neutropenia respectively were 44.12% and 26.47%, whieh were significantly lower than that of the control group （P〈0.05）, but the water-sodium retention, peripheral neurotoxicity, nail changes and skin allergic reactions and other adverse reactions of two groups had no statistioncally significant difference （ P〉0.05 ）. CONCLUSION： The breast cancer patients taking chemotherapy are presenting different adverse reactions, but most of the adverse reactions were below the level of In that patients can tolerate, and the adverse reaction will be improved with effective management.
出处
《转化医学电子杂志》
2015年第9期34-37,共4页
E-Journal of Translational Medicine
关键词
乳腺癌
化疗
不良反应
breast cancer
chemotherapy
adverse reaction
