摘要
目的观察脑栓通胶囊对脑梗死患者血清脂联素(APN)、内脂素(visfatin)和肿瘤坏死因子-α(TNF-α)的影响,探讨脑栓通胶囊对颈动脉粥样硬化的脑梗死患者的治疗机制。方法将56例脑梗死患者根据颈动脉超声检查结果分为颈动脉无病变组6例、内膜增厚组9例、斑块形成组26例、管腔狭窄组15例,采用酶联免疫吸附试验测定各组患者静脉血血清APN、visfatin和TNF-α水平。并将其中50例超声检查诊断有颈动脉粥样硬化的患者随机分为对照组和观察组,每组25例。所有患者均给予脑梗死常规治疗,在此基础上,对照组患者给予阿托伐他汀片治疗,观察组给予脑栓通胶囊治疗,治疗28 d,对比2组患者血清APN、TNF-α、visfatin水平的变化。结果随着患者颈动脉硬化程度加重,血清APN水平呈下降趋势(F=165.377,P<0.01),visfatin和TNF-α水平呈上升趋势(F=240.901、102.603,P<0.01)。与无病变组比较,颈动脉内膜增厚组、斑块形成组、管腔狭窄组患者的血清APN水平均显著降低,visfatin和TNF-α水平均显著增高(P<0.01)。颈动脉斑块形成组、管腔狭窄组患者的血清APN水平均显著低于内膜增厚组,visfatin和TNF-α水平均显著高于内膜增厚组(P<0.01);管腔狭窄组患者的血清APN水平均显著低于斑块形成组,visfatin和TNF-α水平显著高于斑块形成组(P<0.01)。对照组与观察组患者治疗前血清APN、visfatin、TNF-α水平比较差异均无统计学意义(P>0.05)。对照组与观察组患者治疗后的血清APN水平均较治疗前显著增高,而visfatin、TNF-α水平均较治疗前显著降低(P<0.01)。观察组患者治疗后的血清APN、visfatin、TNF-α水平与对照组比较差异均无统计学意义(P>0.05)。结论脑栓通胶囊可通过抑制颈动脉粥样硬化的脑梗死患者血清中visfatin的表达,减少血清中TNF-α的分泌,促进血清APN水平增高,抑制动脉粥样硬化的进程。
Objective To observe the effect of Naoshuantong capsule on adiponectin（ APN）,visfatin and tumor necrosis factor-α（ TNF-α） in serum of cerebral infarction patients with atherosclerosis and explore the therapeutic mechanism of Naoshuantong capsule for cerebral infarction patients with atherosclerosis. Methods Fifty-six patients with cerebral infarction were divided into without disease group（ n = 6）,intima thickening group（ n = 9）,plaque formation group（ n = 26） and stenosis group（ n = 15） according to carotid artery ultrasound results. The APN,visfatin and TNF-α levels in serum in each group were detected by enzyme linked immunosorbent assay. Fifty patients with atherosclerosis who were diagnosed by carotid artery ultrasound were randomly divided into control group and observation group,25 cases in each group. All patients were given conventional therapy; based on these,the patients in control group were given atorvastatin; and the patients in observation group were given Naoshuantong capsule. The levels of APN,visfatin and TNF-α in serum were compared between the two groups after treating for 28 days. Results The levels of serum APN decreased（ F = 165. 377,P〈0. 01） and the levels of visfatin,TNF-α increased（ F = 240. 901,102. 603,P〈0. 01） with the aggravation of the degree of atherosclerosis. Compared with without disease group,the levels of serum APN of patients in intima thickening group,plaque formation group and stenosis group decreased significantly（ P〈0. 01）; while the visfatin and TNF-α levels of patients were increased（ P〈0. 01）. The levels of serum APN of patients in plaque formation group and stenosis group were significantly lower and the levels of visfatin and TNF-αwere significantly higher than those in intima thickening group（ P〈0. 01）. The serum APN level of patients in stenosis group was significantly lower and the levels of TNF-α and visfatin were significantly higher than those in plaque formation group（ P〈0. 01）. There was no s
出处
《新乡医学院学报》
CAS
2015年第11期1002-1005,共4页
Journal of Xinxiang Medical University
基金
河南省教育厅资助课题(编号:2008A320014)
