摘要
[目的]观察治疗前、后反流性食管炎(RE)患者血清PPARγ、HIF-1α水平及其主要症状变化,探讨半夏厚朴汤治疗RE可能机制。[方法]采用简单随机对照设计,40例符合诊断标准、纳入标准和排除标准的反流性食道炎患者,按1:1分为对照组与治疗组。对照组给予泮托拉唑,治疗组予半夏厚朴汤+泮托拉唑治疗,疗程均为4周。采用临床症状评分对患者病情进行评估,应用Western blot技术检测食管黏膜组织中PPARγ及HIF-1α水平。[结果]治疗组总有效率为85%;对照组总有效率为75%,差异无统计学意义。治疗前,各组食道黏膜PPARγ及HIF-1α水平均呈上升趋势;治疗后,治疗组PPARγ及HIF-1α表达均呈下降趋势,经比较,差异有统计学意义(P<0.05),而对照组治疗后,上述指标无明显变化。[结论]半夏厚朴汤可能通过下调PPARγ及HIF-1α表达,改善食道黏膜炎症状态下缺氧微环境变化,发挥缓解反流性食道炎临床症状的效用。
[Objective]To assess the effect of Banxiahoupo Decoction in prevention and treatment of re- flux esophagitis （RE） through observing the re1αted changing expression of PPAR7 and HIF-1α. [Meth- ods]Forty cases of RE patients who met the inclusion criteria, diagnostic criteria and exclusion criteria were randomly divided into intervention group and control group. The control group was given pantorazole for 4 weeks,and the intervention group was given Banxiahoupo Decoction for 4 weeks at the same time. The patients＇ clinical manifestation was evaluated by clinical symptom score. The expression of PPARγ and HIF-1α was detected by western blot. [Results]The total effective rate was 85% in intervention group and 75% in control group. There was no statistical difference between the two groups. Before treatment,the ex- pression of PPARγ and HIF-1α in intervention group was on the rise. After treatment, the expression of PPARγ and HIF-1α tended to decline（P〈0.05）. There was no obvious changes in the expression of PPARγ and HIF-1α in control group before and after treatment. [Conclusion]Banxiahoupo Decoctionn p1αys an effective role in prevention of RE by down-regu1αting the expression of PPAR7 and HIF-1α.
出处
《中国中西医结合消化杂志》
CAS
2015年第11期783-786,共4页
Chinese Journal of Integrated Traditional and Western Medicine on Digestion
关键词
反流性食管炎
半夏厚朴汤
reflux esophagitis
Banxiahoupo Decoction
