摘要
目的：探讨重复经颅磁刺激联合舍曲林治疗帕金森后抑郁的疗效。方法将80例帕金森后抑郁患者按数字表法随机分为研究组、对照组，每组40例。对照组单用舍曲林治疗，研究组采用重复经颅磁刺激联合舍曲林治疗，两组患者均治疗4周。于治疗前及治疗后1、2、4周分别评定汉密尔顿抑郁量表（HAMD）、帕金森病统一评分量表（UPDRS）及副反应量表（TESS）评分，比较两组临床疗效。结果研究组治疗后2、4周 HAMD 评分分别为（18．44±5．56）分、（10．51±4．27）分，均明显低于对照组的（21．23±5．18）分、（14．05±4．10）分（t2周＝-2．322，t4周＝－3．782，均 P ＜0．05）；研究组治疗后2、4周 UPDRS 量表得分分别为（30．14±4．92）分、（28．39±3．38）分，均明显低于对照组的（33．74±4．87）分、（31．09±3．94）分（t2周＝－3．289，t4周＝－3．290，均 P ＜0．05）；研究组临床显效率为77．5％，明显高于对照组的45．0％（χ2＝4．450， P ＜0．05）。结论重复经颅磁刺激联合舍曲林治疗帕金森后抑郁的疗效优于单用舍曲林。
Objective To explore the efficacy of low -frequency repetitive transcranial magnetic stimulation （rTMS）and setraline in treating Parkinson＇s disease patients with depression.Methods 80 cases of Parkinson＇s dis-ease with depression were randomly divided into the study group（administered with rTMS and setraline）and the con-trol group（administered only with setraline）according to random number table,40 cases in each group.Hamilt De-pression Rating Scale（HAMD）,Unified Parkinson＇s Disease Rating Scale（UPDRS）and Treatment Emergent Symp-toms Scale（TESS）were assessed before treatment and 1,2,4 weeks after treatment.Results The scores of HAMD and UPDRS in the study group were lower than those in the control group[the score of HAMD at 2nd week in the study group was （18.44 ±5.56 ）points,the score of HAMD at 4th week in the study group was （10.51 ± 4.27）points,the score of HAMD at 2nd week in the control group was （21.23 ±5.18）points,the score of HAMD at 4th week in the control group was （14.05 ±4.10）points,t2w =-2.322,t4w =-3.782,all P 〈0.05],and the score of UPDRS at 2nd week in the study group was （30.14 ±4.92）points,the score of HAMD at 4th week in the study group was （28.39 ±3.38）points,the score of UPDRS at 2nd week in the control group was （33.74 ±4.87）points, the score of HAMD at 4th week in the control group was （31.09 ±3.94）points （t2w =-3.289,t4w =-3.290,all P 〈0.05）,while the effective rate of the study group（77.5%）was significantly higher than that in the control group （45.0%）（χ2 =4.450,P 〈0.05 ）.Conclusion The efficacy of rTMS combined with setraline for Parkinson ＇s disease with depression is superior to that of using setraline alone.
出处
《中国基层医药》
CAS
2015年第21期3314-3317,共4页
Chinese Journal of Primary Medicine and Pharmacy
关键词
重复经颅磁刺激
舍曲林
帕金森病
抑郁
Repetitive transcranial magnetic stimulation
Setraline
Parkinson＇s disease
Deppression
