摘要
目的:观察脉冲射频联合神经阻滞治疗眼睑带状疱疹神经痛的疗效分析。方法:2011-01/2014-08张家港市第一人民医院诊治的81例81眼眼睑带状疱疹患者,随机分为A、B、C三组。A组27例,全身静滴阿昔洛韦、地塞米松药物治疗。B组27例,在阿昔洛韦抗病毒药物治疗基础上,复方倍他米松等眶上神经阻滞。C组27例,在阿昔洛韦抗病毒药物治疗基础上,予脉冲射频联合神经阻滞治疗。比较三组治疗前,治疗后1、7、30、90d的疼痛视觉模拟评分(visual analogue scale,VAS)、临床治疗效果、并发症等情况。结果:A组患者治疗前,治疗后1、7、30、90d VAS分别为8.2±1.5、7.3±1.6、6.5±1.4、6.1±1.1、5.9±0.7;B组患者治疗前,治疗后1、7、30、90d VAS分别为8.2±1.3、6.3±1.1、5.7±0.9、5.1±1.1、4.1±0.7;C组患者治疗前,治疗后1、7、30、90d VAS分别为8.1±1.5、2.1±0.7、2.2±0.8、2.9±0.7、2.7±0.8。C组患者在脉冲射频联合神经阻滞治疗后疼痛明显缓解,在1、3mo后疼痛评分虽略有恢复,但仍明显低于对照组。三组治疗后第1、7、30、90d VAS评分差异有统计学意义(F=10.320、5.207、2.364、2.805,均P<0.05)。C组患者除减轻疼痛外,无严重并发症,例如角膜知觉减退等,并且角膜炎及角膜溃疡发生的可能减少。结论:脉冲射频联合神经阻滞治疗能迅速减轻疼痛,并减少该疾病引起的并发症,是眼睑带状疱疹神经痛的一种安全、有效的治疗方法。
AIM：To analyze the curative effect of pulsed radiofrequency combined with nerve block in the treatment of eyelid postherpetic neuralgia（PHN）.METHODS：Eighty-one patients（81 eyes） with eyelid herpes zoster from January 2011 to August 2014 in our hospital were randomly divided into three groups（27patients in group A,27 patients in group B and 27 patients in group C）.Patients in group A were treated with intravenous infusion of acyclovir and dexamethasone.Patients in group B were treated with intravenous infusion of acyclovir and supraorbital nerve block using compound betamethasonePatients in group C were treated with pulsed radiofrequency and nerve block along with the same medicine acyclovir.Visual analogue scale（VAS）before treatment and 1,7,30,90 d after treatments,clinical efficacy and complications during the treatments in the three groups were recorded and analyzed.RESULTS：The VAS of patients in group A before treatments and 1,7,30,90 d after treatments were 8.2±1.5,7.3±1.6,6.5±1.4,6.1±1.1,5.9±0.7repectively;those of group B were 8.2±1.3,6.3±1.1,5.7±0.9,5.1±1.1,4.1±0.7;those of group C were 8.1±1.5,2.1±0.7 2.2±0.8,2.9±0.7,2.7±0.8.Pain of patients in group C relieved quickly after treatments of pulsed radiofrequency combined with nerve block.After 1 and 3mo,the VAS of group C rose a little,but still significantly lower than that of the other groups.At 1,7,30 and 90 d after treatments,differences on VAS of three groups were statistically significant（F = 10.320,5.207,2.364,2.805;P〈0.05）.Patients in group C had no severe complications,such as corneal hypoesthesia etc.in addition to relieved pain.The occurrence of keratitis and keratohelcosis in group C were reduced.CONCLUSION：Pulsed radiofrequency combined with nerve block can rapidly relieve the pain of PHN,reduce the complications,and may be a safety and effective method for eyelid postherpetic neuralgia.
出处
《国际眼科杂志》
CAS
2015年第12期2123-2126,共4页
International Eye Science
