摘要
近年来，有关microRNA（miRNA）与肿瘤的研究进展迅速，这给予了诊治肿瘤的新思路——运用miRNA来预测包括肾癌在内的多种肿瘤患者的预后、对肿瘤进行分类、探究崭新的分子机制以辅助免疫治疗。肾癌的发病率大约为成人恶性肿瘤的3％，而能否早期发现往往决定了其预后发展。因此，有关MicroRNAs与癌症的研究显得愈发重要。因而对miRNA在肿瘤转化医学尤其是肾脏肿瘤的研究可为临床肾脏肿瘤的诊断、预后及治疗提供理论基础。
Advances on microRNA （ miRNA ） and cancer have been one of the significant develop- ments in cancer biology over the past decade. The explosion of knowledge in this area provides us a new insight on the diagnosis and therapy for cancer. For years, miRNA are used to predict the prognosis of patients with dif- ferent tumors, tumorous grading and staging, tumor immunotherapy. The renal cell carcinoma accounts for a- round 2% ~ 3% of all cancers,and the key point of prognostic depend on whether the tumor can be confirmed in early stage. Therefore, the relationship between miRNA and cancers, especially the biomarker role of miRNA is increasingly important. In this review, we summarize recent advances in the identification and characterization of miRNA that may be used to establish a novel fundamental concept for the diagnosis, prognosis and irnmunothera- py of renal cell carcinoma.
出处
《国际免疫学杂志》
CAS
2015年第6期567-571,共5页
International Journal of Immunology
基金
基金项目：国家自然科学基金（81171996
81272289）
黑龙江省卫生计生委科研课题（2014-287）
