摘要
目的:观察拉米夫定联合泼尼松对结核性胸膜炎伴HBV感染患者临床治疗效果。方法:选择结核性胸膜炎合并乙肝病毒(HBV)感染患者75例,采用区组随机化法分为治疗组38例及对照组37例,两组均给予3HREZ/9HRE抗结核治疗,治疗组加用拉米夫定及泼尼松治疗;观察两组患者治疗前及治疗3、6月HBV-DNA、肝功能及胸水消失时间、胸膜粘连增厚发生情况。结果:治疗3、6月后,治疗组HBV-DNA逐渐下降,对照组无明显改变,治疗组HBV-DNA水平明显低于对照组(P<0.05);治疗组肝功能损害发生率为15.15%,对照组为43.24%,肝功能损坏发生率明显低于对照组(P<0.01)。治疗组胸水吸收时间,明显短于对照组(P<0.05)。胸膜粘连、增厚发生率治疗组明显小于对照组(P<0.05)。结论:拉米夫定联合泼尼松治疗结核性胸膜炎伴HBV感染患者,既可防治患者HBV的复制和肝功能的损害,又有利于胸水吸收及防止胸膜增厚、粘连。
Objective To Study the effect of lamivudine combined with prednisone on HBV -DNA ,liver function and treatment in tuberculous pleurisy patients complicated with HBV infection.trying to find the treatment strategy.Methods Seventy -five tubercu-lous pleurisy patients complicated with HBV infection were randomly divided into treatment group 38 cases and control group 37 cases, two groups were given 3HREZ /9HRE,The treatment group was treated with lamivudine and prednisone;observe the lever of HBV -DNA ,the liver function Before and after treatment;observe the time of hydrothorax disappearance and the incidence rate of pleural thicken or adhesion.Results The levels of HBV -DNA in treatment group were significantly lower than those of the control group after 3 months and 6 months （P 〈0.05）,liver function damage was significantly lower than the control group （P 〈0.05）.The incidenc rate of plura incrassation and adhesions is lower in the treatment group （P 〈0.05）,and the time of pleural effusion absorption was shorter in treatment group （P 〈0.05 ）.Conclusion Lamivudine combined with prednisone can prevent HBV replication and liver function damage in tuberculous pleurisy patients complicated with HBV infection.It is effective method to treat tuberculous pleurisy worthing to further clinical investigation.
出处
《中国民族民间医药》
2015年第22期68-69,共2页
Chinese Journal of Ethnomedicine and Ethnopharmacy
基金
四川省卫生厅科研课题(130470)
