摘要
目的 :评估大肠癌 (LBC)患者及其家族成员 (FM)血清免疫抑制酸性蛋白 (IAP)水平的变化。方法 :应用单向免疫琼脂扩散法检测 2 0例大肠癌患者和 2 0例家族成员血清IAP水平。结果 :2 0例LBC患者血清IAP水平与正常健康人比较有显著差异 (P<0 .0 1) ,FM组与正常健康人 (NS)比较也有统计学差异 (P <0 .0 1)。结论 :IAP与大肠癌发生可能相关 ,IAP的检测可被用于大肠癌易感个体的筛选。
Purpose: to evaluate the changes af the serum levels of immunosuppressive acidic protein (IAP) in patients with large bowel carcinoma(LBC) and their familial members (FM). Methods: the serum changes of IAP in the 20 cases with LBC and 20 FM were determined using single immunodiffusion method. Results: the serum levels of IAP in patients with LBC, compared with normal subjects (NS), were significantly increased {(P<0.01)}. there also were statistical differences in serum levels between FM and the NS (P<0.01). conclusion: It is suggested that IAP may probably be associated with carcinogenesis of LBC. The changes of IAP may be served as an indicator of diagnosis for susceptible individuals of LBC.
出处
《癌变．畸变．突变》
CAS
CSCD
2002年第1期41-42,共2页
Carcinogenesis,Teratogenesis & Mutagenesis
基金
上海高化公司炼油厂资助
