摘要
目的:观察二甲双胍治疗2型糖尿病(T2DM)合并非酒精性脂肪肝病(NAFLD)的疗效和安全性。方法:106例T2DM合并NAFLD患者随机均分为对照组和观察组。对照组患者接受T2DM合并NAFLD的健康教育,并给予生活干预治疗(糖尿病饮食、运动治疗);观察组患者在对照组治疗的基础上给予二甲双胍片0.5 g,口服,每日3次。两组患者疗程均为12周。观察两组患者的临床疗效,治疗前后肝脏脂肪含量、体质量指数(BMI)、空腹血糖(FPG)、稳态胰岛素评价指数(HOMA-IR)、甘油三酯(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、糖化血红蛋白(Hb A1c)及不良反应发生情况。结果:治疗后,两组患者肝脏脂肪含量、上述指标(除对照组HOMA-IR外)均显著优于同组治疗前,且观察组优于对照组,差异均有统计学意义(P<0.05)。观察组患者总有效率显著高于对照组,差异有统计学意义(P<0.05)。两组患者治疗期间均未见明显不良反应发生。结论 :在常规治疗的基础上,二甲双胍治疗T2DM合并NAFLD的疗效和安全性均较好。
OBJECTIVE：To observe the efficacy and safety of metformin in the treatment of type 2 diabetes（T2DM） with non-alcoholic fatty liver disease（NAFLD）. METHODS：106 patients with T2 DM with NAFLD were randomly divided into control group and observation group. Control group was received health education about T2 DM with NAFLD and living intervention（diabetes diet and physical therapy）;observation group was additionally given Metformin tablet 0.5 g,orally,3 times a day. The treatment course for both groups was 12 weeks. Clinical efficacy,and liver fat content,BMI,FPG,IR,TG,TC,LDL-C,HDL-C,Hb A1 c before and after treatment,and incidence of adverse reactions in 2 groups were observed. RESULTS：After treatment,liver fat content and related index in 2 groups were significantly better than before（except HOMA-IR in control group）,and observaton group was better than control group,the differences were statistically significant（P〈0.05）. The total effective rate in observation group was significantly higher than control group,the difference was statistically significant（P〈0.05）. CONCLUSIONS：Based on the conventional treatment,metformin has good efficacy and safety in the treatment of T2 DM with NAFLD.
出处
《中国药房》
CAS
北大核心
2015年第33期4659-4661,共3页
China Pharmacy
