摘要
真核生物的蛋白质翻译后修饰是蛋白质量控制和稳定性调控的重要因素。其中由泛素和类泛素蛋白介导的修饰广泛参与到亚细胞定位、细胞周期和细胞代谢等多方面调控中,经典的修饰蛋白包括Ub、SUMO、Nedd8、FAT10等。近几年来,由类泛素蛋白即小泛素相关修饰蛋白(SUMO)介导的翻译后修饰动态平衡调控逐渐成为研究热点。该文系统总结了整个SUMO系统的催化反应动态机制和平衡调控原理,并对去SUMO酶SENP1与肿瘤发生、免疫调控和发育稳态维持的关系进行了总结。
Post-transcriptional regulation of prokaryotes is of pivotal importance to the quality control and stability main- tenance of multiple proteins. The ubiquitin and ubiquitin-like proteins-mediated modifications have widely participated in the manipulation of cell cycle control, subcellular localization and cellular metabolisms. Typical ubiquitin like proteins （UBLs） are ubiquitin, SUMO, Nedd8 and FAT10. Recently, the dynamic regulation mechanisms between sumoylation and de-sumoylation have become the cutting edge in the era of ubiquitin-like modifications. In this review, we briefly summa- rized the entire SUMO-mediated modification systems and the intricate balance regulation. We also discussed the counter acting star molecule SENP1 and its relationship with tumor initiation and progression, immunological regulation and develop- mental homeostasis.
出处
《军事医学》
CAS
CSCD
北大核心
2015年第10期805-807,共3页
Military Medical Sciences
基金
国家自然科学基金资助项目(81470320
81402558)
关键词
SUMO
SENP1
肿瘤生成
免疫调控
发育稳态
SUMO
SENP1
tumorigenesis
immunological regulation
developmental homeostasis
