HLA-DRB1和HLA-DQB1基因与肝癌及肺癌的相关性研究
摘要
目的：通过对肝癌及肺癌患者HLA-DRB1、DQB1等位基因位点的检测，探讨HLA-DRB1、DQB1基因多态性与肝癌和肺癌的关联性。方法采用PCR-SSP技术，检测50例肝癌患者、54例肺癌患者的HLA-DRB1、HLA-DQB1基因位点18个，并以100名健康志愿者作为对照。结果肝癌组及肺癌组HLA-DQB1＊03型频率明显高于对照组，HLA-DQB1＊06型频率明显低于对照组，差异有统计学意义（P〈0.05）；肝癌组和肺癌组之间差异无统计学意义。结论 HLA-DQB1＊03可能是肿瘤的易感基因；HLA-DQB1＊06可能是肿瘤的抗性基因。
出处
《中国临床实用医学》
2015年第5期41-43,共3页
China Clinical Practical Medicine
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