摘要
视黄酸受体(RAR)家族成员包括RAR与视黄酸X受体两大类,它们由3种不同的基因α、β、γ编码,由此形成不同的受体亚型。与其他受体一样,RARα参与调控细胞分化、增殖、凋亡以及胚胎发育、视觉形成、骨骼形成、新陈代谢、造血等许多关键的生命活动过程,并且RARα的异常表达具有肿瘤相关性和组织差异性。现就RARα在肿瘤中的研究情况进行综述。
Retinoic acid receptor （RAR） family member including RAR and retinoid X receptor two categories, which consists of three different genes α、β、γ, thereby forming different receptor subtypes. Like with other receptors, RARer involves in the regulation of cell differentiation, proliferation, apoptosis, and embryonic development, visual formation, bone formation, metabolism, blood and many other key life activities. Meanwhile, there are the high correlation and tissue differentiation between abnormal expression of RARα and tumor. Here is to make a review on RARα and tumor.
出处
《中国医药导报》
CAS
2015年第33期52-55,共4页
China Medical Herald
基金
国家自然科学基金面上项目(81572394)
福建省卫生系统中青年骨干人才培养项目(2015-ZQN-ZD31)
福建省自然科学基金计划项目(2015J01560)
关键词
视黄酸受体α
肿瘤
核受体
视黄酸受体家族
Retinoic acid receptor α
Tumor
Nuclear receptor
Retinoic acid receptor family
