摘要
目的观察蒙诺对原发性高血压患者血压的抑制作用及其对肾功能的影响。方法符合原发性高血压诊治标准60例,其中男35例,女25例。开始口服蒙诺10 mg/次,1次/d;7 d后血压未降至140/90 mm Hg(1 mm Hg=0.133 k Pa)以下者,蒙诺改为20 mg/次,1次/d;14 d后依然未达到140/90 mm Hg以下者蒙诺改为30 mg/次,1次/d;21 d后未达到140/90 mm Hg以下者蒙诺改为40 mg/次,1次/d。治疗前及用药期间监测血压,45 d后测定血尿素氮(BUN)及血肌酐(SCr)。结果口服蒙诺后患者平均收缩压明显下降,治疗前后分别为(185.32±11.22)mm Hg和(138.22±12.11)mm Hg,差异有统计学意义(P<0.01);平均舒张压治疗前为(103.23±6.33)mm Hg,治疗后为(83.12±4.36)mm Hg,差异有统计学意义(P<0.01);治疗前BUN和SCr已有升高者,治疗后BUN和SCr均明显下降(P<0.05)。结论蒙诺对原发性高血压具有理想的降压作用,对患者肾功能具有一定的保护作用。
Objective To investigate the effect of monopril for the blood pressure control and renal function for patients with primary hypertension. Methods Sixty cases with primary hypertension（ male 35 and female 25） take orally monopril（ 10 mg,qd）. After 7 days,for the cases whose blood pressure was more than 140 /90 mm Hg（ 1 mm Hg = 0. 133 k Pa）,the dose of the drug were changed to 20 mg（ qd）; after 14 days,for the cases whose blood pressure was more than 140 /90 mm Hg,the dose of the drug were changed to 30 mg（ qd）; after 21 days,for the cases whose blood pressure was more than 140 /90 mm Hg,the dose of the drug were changed to 40 mg（ qd）. The blood pressure was monitored before and after treatment. After 45 days,the serum Cr and BUN were also examined. Results After taking monopril,mean systolic blood pressure decreased from（ 185. 32 ± 11. 22）mm Hg to（ 138. 22 ± 12. 11） mm Hg（ P〈0. 01）; the average diastolic pressure decreased from（ 103. 23 ± 6. 33） mm Hg to（ 83. 12 ± 4. 36） mm Hg（ P〈0. 01）. In the cases whose serum BUN and Cr level were abnormally high,the BUN and Cr were obviously decreased（ P〈0. 01）. Conclusion Monopril is an ideal drug for cases with primary hypertension to control blood pressure and protect the renal function.
出处
《临床医学》
CAS
2015年第10期6-7,共2页
Clinical Medicine
关键词
蒙诺
原发性高血压
治疗
肾功能
Monopril
Primary hypertension
Treatment
Renal function
