摘要
Exosomes是可由体内多种活细胞分泌的纳米级双层膜结构小囊泡，可运载核酸、蛋白质和脂质等生物信息物质。Exosomes可保护易在循环系统中失活或降解的信息物质（如miRNA），将它们安全转移至特异性的靶细胞中参与信号调节，在细胞间信息传递中发挥重要的作用。Exosomes广泛存在于人类血液、尿液、胸腹腔积液等多种体液样本中，并可提供丰富、稳定、灵敏且特异的生物信息，是应用价值很高的液体活检标本。
Exosome is nanoscale vesicles with bilayer membrane structure, is secreted by multiple living cells in vivo, capable of carrying biological materials such as nucleic acids, proteins and lipids etc. Exosome can protect the information material （ such as miRNA）, which is easy to be inactivated or degraded in the circulatory system, so that they can be safely transferred to the specific target cells to participate in signal regulation, and play an important role in the information transmission between cells. Exosome is widely found in human blood, urine, pleural effusion and other body fluid samples, and can provide rich, stable, sensitive and specific biological information. As a kind of liquid biopsy specimen, exosome has a very high clinical application value in the future.
出处
《中华检验医学杂志》
CAS
CSCD
北大核心
2015年第11期724-726,共3页
Chinese Journal of Laboratory Medicine
基金
国家自然科学基金资助项目（81371901）
广州市科技计划资助项目（1563000220）
