摘要
目的分析研究慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD)患者血脂水平、瘦素和脂联素的变化及意义。方法选择2014年2—8月在本院呼吸内科住院治疗的106例COPD患者为观察组,选择同期健康体检者100例为对照组,比较观察组和对照组的TC、TG、HDL-C、LDL-C、载脂蛋白A1(apolipoprotein A1,APo A1)、载脂蛋白B(apolipoprotein B,APo B)、瘦素和脂联素水平。计量资料采用t检验,P<0.05为差异有统计学意义。结果观察组血清TC[(4.22±0.50)mmol/L]、TG[(1.29±0.31)mmol/L]均低于对照组[(4.80±0.37)、(1.60±0.23)mmol/L],组间比较差异均有统计学意义(P<0.05);观察组Apo B水平[(0.68±0.20)g/L]比对照组[(0.95±0.77)g/L]降低,差异有统计学意义(P<0.05)。观察组瘦素水平为[(0.38±0.07)mg/ml]低于对照组[(0.50±0.04)mg/ml],差异有统计学意义(t=14.988,P<0.05);观察组脂联素水平为[(0.53±0.17)mg/L]高于对照组[(0.42±0.05)mg/L],差异有统计学意义(t=6.221,P<0.05)。结论血清瘦素和脂联素对COPD患者的诊断有重要的参考价值。血脂相关指标与COPD患者病情发展有相关性,因此在此类人群中进行血脂等指标检查十分必要。
Objective To investigate the changes and significance of blood lipid,leptin and adiponectin in patients with chronic obstructive pulmonary disease（ COPD）. Methods A total of 106 patients with COPD were recruited from respiratory medicine in the 242 hospital of Shenyang from February to August in 2014 as observation group. Healthy control at the same period were selected as control group（ n = 100）. TC,TG,HDL- C,LDL- C,APo A1,APo B,leptin and adiponectin levels in the two groups were compared. Measurement data was processed by t test,P〈0. 05 was considered statistically significant. Results Serum TC [（ 4. 22 ± 0. 50） mmol / L] and TG levels [（ 1. 29 ± 0. 31） mmol / L] in observation group were significantly lower than that in control group [（ 4. 80 ± 0. 37）,（ 1. 60 ± 0. 23） mmol / L]（ P〈0. 05）. Apo B level[（ 0. 68 ± 0. 20） g/L]of the observation group was lower than that of the control group[（ 0. 95 ± 0. 77） g/L]（ P〈0. 05）.Serum leptin level[（ 0. 38 ± 0. 07） mg / ml〗 was significantly decreased and serum adiponectin level[（ 0. 53 ± 0. 17） mg / L]was significantly increased in observation group,compared with control group[（ 0. 50 ± 0. 04） mg / ml,（ 0. 42 ± 0. 05） mg /L]（ P〈0. 05）. Conclusions Serum leptin and adiponectin levels play crucial roles in the diagnosis of chronic obstructive pulmonary disease. Blood lipid index is associated with the development of COPD. Therefore,it is necessary to detect blood lipid indexes in patients with COPD.
出处
《社区医学杂志》
2015年第20期10-11,共2页
Journal Of Community Medicine
关键词
慢性阻塞性肺疾病
血脂
瘦素
脂联素
Chronic obstructive pulmonary disease
Blood lipid
Leptin
Adiponectin
