摘要
目的:探讨FAP、TGF-β1蛋白在卵巢癌发生发展中的作用、表达及相关病理机制。方法:采用免疫组化法检测正常卵巢(10例)、卵巢癌(50例)组织中FAP、TGF-β1蛋白表达。结果:卵巢癌组织中FAP、TGF-β1蛋白表达显著高于正常卵巢组织(P<0.05);其蛋白表达与卵巢癌组织分化程度呈负相关(P<0.05),与临床病理分期正相关(P<0.05);卵巢癌组织中FAP、TGF-β1蛋白表达增高与卵巢癌淋巴结转移及有无腹水相关(P<0.05);在卵巢癌组织中,FAP与TGF-β1蛋白表达呈正相关(r=0.605,P=0.000)。结论:在卵巢癌组织中,同时存在FAP和TGF-β1蛋白高表达,其高表达与卵巢癌的组织分化程度、临床病理分期和转移能力密切相关,可作为判定卵巢癌发生及侵袭能力的一项有效客观指标,因此,构成了卵巢癌发生和侵袭的分子基础,并有可能成为卵巢癌治疗的靶点。
Objective： To investigate the role of protein expression of FAP and TGF-β1 in tumorigenesis and progression of ovarian cancer and its relevant pathological mechanisms. Methods： We examined protein expression of FAP and TGF-β1 in normal ovary（ 10 cases） and ovarian cancer（ 50 cases） by the immunohistochemistry. Results： Protein expression of FAP and TGF-β1 was significantly higher in ovarian cancer than that in normal ovary（ P〈0. 05）. Protein expression level of FAP and TGF-β1 were negatively correlated with histological differentiation（ P〈0. 05）,but positively with clinicopathological staging of ovarian cancer（ P〈0. 05）. Increased protein expression level of FAP and TGF-β1 were related to lymph node metastasis and ascites of ovarian cancer（ P〈0. 05）. Protein expression level of FAP was positively correlated with expression level of TGF-β1（ r = 0. 605,P = 0. 000）. Conclusion： Increasing protein expression of FAP and TGF-β1 was sociated with histological differentiation,clinicopathological staging and lymph node metastasis of ovarian cancer. These results suggested that up-regulated protein expression of FAP and TGF-β1 participate in tumorigenesis and progression of ovarian cancer,which therefore constituted molecular basis of the tumorigenesis and invasion and might offer an important target for anticancer therapy of ovarian tumor.
出处
《现代肿瘤医学》
CAS
2015年第23期3500-3503,共4页
Journal of Modern Oncology
基金
辽宁省科学技术计划项目(编号:2013225021)
辽宁省人力资源社会保障厅"百千万人才工程"支助项目(编号:2012921031)
