摘要
目的探讨纤维支气管镜（FB）联合痰液细胞角蛋白19片段抗原（CYFRA21-1）、胚胎抗原（CEA）和糖类抗原125（CA125）检查对肺癌的诊断价值。方法 2013年1月至2014年12月间对45例经病理组织学确诊为肺癌（肺癌组）及40例肺部良性病变（肺部病变组）患者行FB检查,并采用酶联免疫吸附法（ELISA）法测定两组患者痰液中肿瘤标志物（CYFRA21-1、CEA、CA125）的表达。比较两组患者的检测结果。结果肺癌组患者FB检查阳性率、CYFRA21-1、CEA、CA125阳性率均高于良性肺部病变组,差异有统计学意义（P〈0.05）。肺癌组患者中,Ⅲ~Ⅳ期患者FB检查阳性率、CYFRA21-1、CEA、CA125阳性率高于Ⅰ~Ⅱ期组（P〈0.05）。FB联合痰液肿瘤标志物敏感度、特异度和准确率高于单一指标的敏感度、特异度和准确率（P〈0.05）。结论纤维支气管镜联合痰液肿瘤标志物能有效提高肺癌患者临床诊断的准确性。
Objective To explore the diagnostic value of bronchoscopy and sputum cytokeratin-19fragment（ CYFRA 21-1）,carcino-embryonic antigen（ CEA）,carbohydrate antigen 125（ CA125） for lung cancer. Methods 40 cases of lung lesions and 45 cases of histologically diagnosed with lung cancer were examined with underwent fiber mirror（ FB） and the levels of CYFRA21-1,CEA,CA125 were measured with enzyme-linked immunosorbent assay（ ELISA）. The examination results were compared in the two groups. Results The positive rates of FB,CYFRA21-1,CEA,CA125 of lung cancer groups were higher than those of benign lung disease group（ P 0. 05）. The FB,CYFRA21-1,CEA and CA125 positive rate in patients with Ⅲ ~ Ⅳ stage lung cancer were higher than those of Ⅰ ~ Ⅱ stage group（ P 0. 05）. The sensitivity,specificity and accuracy of FB combined with tumor markers were higher than single factor（ P 0. 05）. Conclusion The FB combined with sputum tumor markers can improve the accuracy and sensitivity of clinical diagnosis in lung cancer patients.
出处
《中国肿瘤临床与康复》
2015年第11期1300-1302,共3页
Chinese Journal of Clinical Oncology and Rehabilitation
