摘要
目的：探讨奈达铂在宫颈癌化疗中的临床应用价值。方法：收集2012年1月至2013年12月间在安徽省立医院妇科接受术后辅助化疗的宫颈癌患者资料。选取ⅠB1期～ⅡB期，且术后病理检查提示为宫颈鳞状细胞癌的患者。根据其与紫杉醇联合化疗中选用铂类药物的不同，分为奈达铂组（NDP组）与顺铂组（DDP组）。对两组患者的化疗毒副反应、治疗费用、住院时间进行比较。结果：符合标准的患者共82例，NDP组39例，中位年龄45岁；DDP组43例，中位年龄43岁。NDP组共行化疗156疗程，DDP组共行化疗170疗程。NDP组患者恶心、呕吐的发生率为18．59％，明显低于DDP组（58．82％）（P〈0．05）。白细胞减少（43．59％vs32．35％）、血小板减少（26．92％VS8．82％）发生率高于DDP组（P〈0．05）。NDP组与DDP组患者人均每次化疗住院费用分别为4970．05±405．00元与4242．26±826．00元，两者差异无统计学意义（P〉0．05）。NDP组与DDP组平均住院天数分别为3．00±0．63天与4．73±0．78天，两者差异有统计学意义（P〈0．05）。结论：铂类药物联合紫杉醇为宫颈癌患者化疗的一线方案，NDP组较DDP组的胃肠道毒性更低，骨髓抑制虽然增加但可控。采用NDP化疗较DDP缩短了住院时间，且住院费用并无显著升高，更易被患者接受。
Objective ：To investigate the clinical application value of nedaplatin for the chemotherapy in cervical cancer. Methods：Data of patients with cervical cancer who received adjuvant chemotherapy after surgical resections were collected at the Gynecological Department of Anhui Provincial Hospital from January 2012 to December 2013. The patients staging from ⅠB1 to ⅡB,whose postoperative pathological classification were squamous cell carcinoma were selected. Patients were divided into two groups（ NDP group and DDP group）to compare the adverse reaction,toxicity,treatment cost and average hospital stay. Results： Myelosuppression in the NDP group was severer than that in the DDP group, especially with the respect to leucopenia,anemia and thrombocytopenia. The NDP group showed a lower incidence of gastrointestinal toxic reaction than the DDP group（18. 59% vs 58. 82%,P 〈0. 05）. The incidence of leukopenia（43. 59% vs 43. 59% ）and thrombocytopenia（26. 92% vs 8. 82% ）was higher then DDP group （ P 〈 0. 05）. The treatment cost in the NDP group was 4970. 05 ±405. 00 yuan, compared to 4242. 26 ±826. 00 yuan in the DDP group（ P〉0. 05）. The average hospital stay was 3. 00 ±0. 63 and 4. 73 ±0. 78 respectively（ P 〈0. 05）. Conclusions： Platinum drugs in combination with paclitaxel are the first-line chemotherapy in patients with cervical cancer. NDP group showed a lower incidence of gastrointestinal complication including nau- sea and vomiting. The incidence of myelosuppression was higher,but controllable. The average stay in the NDP group was shorter,with no significant increase in the treatment cost,which makes it more easily accepted by patients.
出处
《实用妇产科杂志》
CAS
CSCD
北大核心
2015年第11期862-865,共4页
Journal of Practical Obstetrics and Gynecology
关键词
宫颈癌
奈达铂
顺铂
辅助化疗
Cervical cancer
Nedaplatin
Cisplatin
Adjuvant chemotherapy
