摘要
目的了解DM／PM患者主要死因的变化，分析影响DM／PM患者病死率和主要死因的因素。方法回顾分析1985年8月至2013年4月北京协和医院DM／PM住院患者的死亡病例。应用X2检验和Fisher确切概率法对计数资料进行分析；用独立样本的t检验对计量资料进行分析。结果近28年DM／PM的住院患者共1443例，死亡患者74例，总病死率5．1％，其中女性48例（4．7％），男性26例（6．3％）；DM／PM最常见的死因为感染（46例，62．2％）和呼吸系统受累（11例，14．9％）。DM／PM发病后第1年内死亡人数最多，占总死亡人数的79．7％（59／74），感染和呼吸系统受累是发病后第1年内最常见的死因。近28年住院DM／PM患者的病死率在1996-2000年达到高峰（12．3％，18／146）；DM／PM患者最常见的死亡原因为感染。结论感染、呼吸系统受累是DM／PM的最主要死因，DM／PM发病第1年内死亡最多见。
Objective To investigate the changes of major causes of death in patient with dermatomyositis/polymyositis （DM/PM） and the factors affecting the mortality of DM/PM in the past 28 years. Methods Death cases with DM/PM from 1985 to 2013 were retrospectively analyzed. ）（2 test and Fisher exact test was used for count data analysis; independent samples t-test measurement was used for data analysis; P〈0.05 was consi-dered statistically significant. Results Out of 1 443 patients with DM/PM, 74 died, in whom 48 were female and 26 were male. The mortality rate was 4.7% among female and 6.3% among male cases and the total in-hospital mortality of DM/PM was 5.1%.The two most common causes of death in patients with DM/PM were infection and respiratory involvement, accounting for 62.2% （46/74） and 14.9% （11/74） respectively. Death occurred most commonly in the first year after disease onset, accounting for 79.7%（59/74）. The leading causes of death in the first year were infection and respiratory involvement. The mortality of DM/PM patients was peaked 12.3%（18/146） from 1996 to 2000; infection was the most frequent cause of death. Conclusion Infection and respiratory involvement are the main causes of death in DM/PM. Death occurrs most commonly in the first year after disease onset.
出处
《中华风湿病学杂志》
CAS
CSCD
北大核心
2015年第10期669-673,共5页
Chinese Journal of Rheumatology
基金
国家自然科学基金面上项目（81471615）
2013-2014年北京协和医科院协和青年基金
关键词
皮肌炎
死亡原因
医院死亡率
Dermatomyositis
Cause of death
Hospital mortality
