摘要
目的探讨健康成人的糖代谢调节状态与血清25羟维生素D3[25(OH)D]水平的关系。方法 102名健康成人根据稳态模型评估的胰岛B细胞功能指数(HOMA-B)、胰岛素分泌指数(IS)、胰岛素敏感性指数(IAI)、胰岛素抵抗指数(HOMA-IR)这四个指标来评价其糖代谢调节状态,并根据其血清25(OH)D水平分为25(OH)D降低组和正常组,比较2组的临床资料,对呈非正态分布的25(OH)D、HOMA-B、IS、HOMA-IR进行对数转换,通过Pearson相关分析和多重线性回归探讨糖代谢指标与血清25(OH)D水平的关系。结果64例(62.7%)受试者的血清25(OH)D水平降低,25(OH)D降低组的Lg(HOMA-B)、Lg(IS)、IAI均显著低于正常组(P<0.05),Lg(HOMA-IR)显著高于正常组(P<0.05)。Lg[25(OH)D]与Lg(HOMA-B)、Lg(IS)、IAI成正相关(P<0.05),与Lg(HOMA-IR)成负相关(P<0.05)。结论 25(OH)D有利于提高胰岛B细胞的功能及胰岛素的敏感性,血清25(OH)D水平降低的人群可适当补充维生素D。
Objective To investigate the relationship between the state of sugar metabolic regulation and serum 25 -hydroxyl Vitamin D3[25（OH）D] levels of healthy adult. Methods A total of 102 healthy adults who were received health examination in our hospital were enroll for the study.Their state of sugar metabolic regulation were evalua-ted through the homeostasis model assessment B cell function index （ HOMA-B） , secretion index （ IS ） , the sensitive index （ IAI ） , and insulin resistance index （ HOMA-IR）.Healthy adults cases were divid-ed into the 25（ OH） D reduction group and normal group according to the serum 25 （ OH ） D level. Clinical data were compared between two groups.25 （ OH ） D, HOMA-B, IS, HOMA -IR followed abnormal distribution were analyzed by logarithmic transformation. Pearson correlation analysis and multiple linear regression analysis were performed to investigate the relationship between the index of sugar metabolic regulation and serum 25-hydroxyl Vitamin D3 levels. Results The serum 25（OH）D level of 64 cases （62.7%） decreased.Lg（HOMA-B）, Lg（IS）, IAI of the 25（OH）D reduction group were significantly higher than those of normal group （ P〈0.05 ） , and Lg （ HOMA -IR ） was significantly lower than that of normal group（P〈0.05）.Lg[25（OH）D] was positively correlated with Lg（HOMA-B）, Lg（IS）,IAI（P〈0.05）,andnegativelycorrelatedwithLg（HOMA-IR）（P〈0.05）.Conclusion 25（OH）D could improve the function of pancreatic islet B cell and sensitivity of insulin, thus the adults with decreased serum 25 （ OH） D level are advised to receive appropriate VD supplement.
出处
《中国临床药理学杂志》
CAS
CSCD
北大核心
2015年第21期2105-2107,共3页
The Chinese Journal of Clinical Pharmacology
基金
河北省卫计委医学科学研究重点课题计划基金资助项目(20150055)
张家口市科技局指令性计划基金资助项目(1421115D)
