摘要
目的：探讨孟鲁司特钠联合妥洛特罗贴剂在儿童咳嗽变异性哮喘（CVA）治疗中的价值。方法将医院2012年1月～2014年1月收治的116例CVA患儿随机分为2组，对照组采用孟鲁司特钠治疗，观察组采用孟鲁司特钠联合妥洛特罗贴剂治疗，比较2组患儿肺功能改善情况、咳嗽缓解和消失时间、治疗总有效率，并比较2组治疗前后血清白细胞介素‐4（IL‐4）、γ干扰素（IFN‐γ）水平变化情况。结果治疗前2组FVC、FEV1、PEF差异无统计学意义；治疗后2组上述指标均增加，且观察组各项指标均高于对照组，差异均有统计学意义（P＜0．05）；观察组咳嗽缓解、消失时间短于对照组（P＜0．05），观察组总有效率高于对照组（X2＝5．583，P＝0．018），差异有统计学意义。治疗前2组患儿血清IL‐4、IFN‐γ水平差异无统计学意义，治疗后2组血清IL‐4降低，观察组低于对照组，IFN‐γ水平升高，观察组高于对照组（ P＜0．05）。结论孟鲁司特钠联合妥洛特罗贴剂治疗儿童CVA可有效改善肺功能、缓解咳嗽症状，提高临床疗效。
Objective To investigate the effect of montelukast combined with tulobuterol patch on cough variant asthma （CVA） in children .Methods 116 children patients with CVA admitted to the Xili People′s Hospital in Nanshan District from January ,2012 to January ,2014 were randomly divided into two groups ,with 58 cases in each group .The control group were treated with monte‐lukast ,while the observation group were treated with montelukast combined with tulobuterol patch .The improvement condition of pulmonary function ,cough relieving and disappearing time ,the total efficiency of the treatment of children in two groups were compared .The serum leukocyte mediated‐4 （IL‐4） ,interferon gamma （IFN‐gamma） changes before and after the treatment were measured .Results There was no statistically significant difference in FVC ,FEV1 ,PEF before the treatment ,while the indexes a‐bove mentioned increased after the treatment .The indicators of the observation group were higher than that of the control group （P〈 0 .05） .The symptom remission time and disappearance of cough of the observation group were shorter than those of the con‐trol group ,and there was statistically significant difference （P〈 0 .05） .The total effective rate of the observation group was high‐er than that of the control group （X2 =5 .583 ,P=0 .018） ,and the difference was statistically significant .There was no statistical‐ly significant difference in serum IL‐4 ,IFN‐levels before the treatment between the two groups ,while serum IL‐4 decreased after the treat‐ment .The observation group was lower than that of the control group ,IFN‐levels increased .The observation group was higher than that of the control group（P〈 0 .05） .Conclusion Montelukast combined with tulobuterol patch on CVA in children can ef‐fectively improve the lung function ,relieve cough symptoms ,and improve the clinical curative effect .
出处
《西北药学杂志》
CAS
2015年第6期737-739,共3页
Northwest Pharmaceutical Journal
