摘要
目的 探讨小剂量右美托咪定抑制非老年高血压患者插管反应的疗效,分析其最佳有效剂量及安全性,确定最佳有效剂量. 方法 选取笔者医院2013年1月~2014年8月非老年高血压患者100例,择期行手术全身麻醉气管插管,随机分为对照组和试验组,各50例,试验组给予右美托咪定0.6μg/kg,对照组给予右美托咪定1.0μg/kg. 观察记录两组基础值15min （T0）、诱导前即刻（T1）、插管前即刻（T2）、插管后1min（T3）的平均动脉压（MAP）、呼吸（HR）、心率（RR）、血氧饱和度（SpO2）、收缩压（SBP）、舒张压（DBP）,进行非劣效性分析并观察不良反应. 结果 两组患者在麻醉插管后HR、RR、SpO2、SBP和DBP均有降低,对照组和试验组患者插管后1min MAP的变化率分别为15.3%和15.1%. 试验组患者不良反应结果为4.00%（2/50）,显著低于对照组14.00%（7/50）,（ P〈0.05）. 结论 0.6μg/kg 右美托咪定抑制非老年高血压患者插管反应的疗效不低于1.0μg/kg,并且可以降低不良反应的发生.
Objective To explore noninferiority of low dose of dexmedetomidine on inhibiting anesthesia intubation -induced cardio-vascular response in non -senile hypertension patients .We analyzed the best effective dose and safety , and determined the best effective dose.Methods One hundred non-senile hypertension patients with elective surgical tracheal intubation general anesthesia were selected in the hospital from January in 2013 to August in 2014.They were randomly divided into the control group and the experimental group e -venly （n=50 in each group）.They received 1 or 0.6μg/kg of dexmedetomidine, respectively.Baseline observation records in the two groups before 15min （T0）, inducing immediate （T1）, immediately before intubation （T2）, 1 min after intubation （T3）, mean arterial pressure （MAP）, respiratory （HR）, heart rate （RR）, blood oxygen saturation （SpO2）, systolic blood pressure （SBP）, diyuastolic blood pressure （ DBP） , adverse reactions were observed .The noninferiority analysis were also performed .Results HR, RR, SpO2 ,SBP and DBP decreased in two groups after anesthesia or intubation .Variation rate of post-intubation 1 min MAP in experimental or control group were 15.3%and 15.1%, respectively.The adverse effects rates in experimental group was more lower than control group .Conclu-sion Inhibition of anesthesia intubation -induced cardiovascular response in non -senile hypertension patients by 0.6 or 1.0μg/kg of dexmedetomidine is noinferior .
出处
《医学研究杂志》
2015年第10期86-89,共4页
Journal of Medical Research
基金
温州市科技局医疗卫生基金资助项目(Y20140321)
关键词
右美托咪定
高血压
插管
心血管反应
非劣性分析
Dexmedetomidine
Hypertension
Intubation
Cardiovascular response
Noninferiority
